2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Tedisamil dihydrochloride

Tedisamil dihydrochloride  (Synonyms: KC-8857 dihydrochloride)

目录号: HY-126704A
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Tedisamil (KC-8857) (dihydrochloride) 是一种抗心律失常化合物，具有重要的生物学活性。Tedisamil (dihydrochloride) 表现出明显的缓慢心率作用，这是通过抑制心房的瞬时外向钾电流 (I(to)) 实现的。Tedisamil (dihydrochloride) 能抑制多种钾电流，包括 IK、K(ATP) 和 PKA 激活的氯离子通道，从而延长心脏动作电位和 QT 间期，并增加心脏的折返性。Tedisamil (dihydrochloride) 在动物模型中对室性心律失常和心房扑动具有抗心律失常效果。

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Tedisamil dihydrochloride

Tedisamil dihydrochloride Chemical Structure

CAS No. : 132523-84-3

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Tedisamil dihydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tedisamil (KC-8857) (dihydrochloride) is an antiarrhythmic compound with important biological activities. Tedisamil (dihydrochloride) exhibits a significant slowing effect on heart rate, which is achieved by inhibiting the transient outward potassium current (I(to)) in the atrium. Tedisamil (dihydrochloride) inhibits multiple potassium currents, including IK, K(ATP), and PKA-activated chloride channels, thereby prolonging the cardiac action potential and QT interval, and increasing cardiac reentry. Tedisamil (dihydrochloride) has antiarrhythmic effects on ventricular arrhythmias and atrial flutter in animal models[1].

分子量

361.39

Formula

C19H34Cl2N2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tedisamil dihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tedisamil132523-84-3KC-8857KC8857KC 8857Potassium ChannelKcsAInhibitorinhibitorinhibit

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