2. Immunology/Inflammation Anti-infection
  3. Toll-like Receptor (TLR) HBV IFNAR Interleukin Related
  4. TLR7/8 agonist 13

TLR7/8 agonist 13 是一种具有口服活性的 TLR7 (最低有效浓度 (LEC) [hTLR7] = 1.6 μM) 和 TLR8 (LEC [hTLR8] = 1.6 μM) 双重激动剂。TLR7/8 agonist 13 对人外周血单核细胞 (hPBMC) 有激动活性 (LEC [hPBMC] = 0.5 μM)。TLR7/8 agonist 13 在小鼠和食蟹猴体内诱导内源性 IFNα，激活髓系树突状细胞和单核细胞，使其向 TH1 表型转变。TLR7/8 agonist 13 在慢性 AAV-HBV 小鼠模型中，降低病毒载量和 HBV 表面抗原。TLR7/8 agonist 13 具有间接诱导 IFNγ 的潜力，可以促进 HBV 抗原特异性 CD8 T 细胞介导的应答的产生。TLR7/8 agonist 13 可用于研究乙型肝炎病毒。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

TLR7/8 agonist 13

TLR7/8 agonist 13 Chemical Structure

CAS No. : 1402802-45-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

TLR7/8 agonist 13 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (lowest effective concentrations (LEC) [hTLR7] = 1.6 μM) and TLR8 (LEC [hTLR8] = 1.6 μM). TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells (hPBMCs) (LEC [hPBMC] = 0.5 μM). TLR7/8 agonist 13 induces endogenous IFNα, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus[1].

IC50 & Target[1]

human TLR7

 

TLR8

 

体外研究
(In Vitro)

TLR7/8 agonist 13 (Compound 50 d) 诱导 PBMCs 产生 IFNα、IFNγ、IL-12p40、IL-12p70 和 TNF-α[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TLR7/8 agonist 13 相关抗体:
体内研究
(In Vivo)

TLR7/8 agonist 13 (Compound 50 d) (1-50 mg/kg，口服，一次) 在 C57Bl/6 小鼠模型中诱导 IFNα、TH1 和髓系应答[1]。
TLR7/8 agonist 13 (5 mg/kg，口服，每周一次，8 周) 通过两种不同的非细胞毒性机制在 AAV-HBV C57Bl/6 小鼠模型中抑制 HBsAg 分泌和 HBV 病毒载量[1]。
TLR7/8 agonist 13 (3-30 mg/kg，口服，一次) 在食蟹猴中诱导内源性 IFNα，同时激活髓系树突状细胞和单核细胞，使其向 TH1 表型发展[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice model[1]
Dosage: 1, 5, 10, and 50 mg/kg
Administration: p.o. once
Result: Induced IFNα at low dose as well as TH1 and myeloid responses at higher doses.
Animal Model: AAV-HBV C57Bl/6 mice model[1]
Dosage: 5 mg/kg
Administration: p.o., once a week, 8 weeks
Result: Decreased HBsAg levels by 2.4 log at the end of the dosing period, decreased the percent of HBsAg hepatocytes, decreased HBV viral load in the serum, had no decrease in liver HBV RNA levels nor in the percent of HBcAg hepatocytes.
Increased serum anti-HBsAg antibody levels.
Animal Model: cynomolgus monkeys model[1]
Dosage: 3, 9, and 30 mg/kg
Administration: p.o., once
Result: Had no change of clinical observations and body weight, body temperature, clinical pathology.
Induced IFNα production from the 9 mg/kg dose, induced an ISG response and CXCL10 from a lower dose than IFNα, i.e., 3 mg/kg.
Up-regulated Isg15 and Mx1, activated monocytes, IL-15 from 9 mg/kg, activated Myeloid dendritic cells, MCP1, MIP-1β, and IL-1Ra from 3 to 9 mg/kg, activated TNFα and IL-6 from 30 mg/kg.
分子量

254.33

Formula

C12H22N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TLR7/8 agonist 13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7/8 agonist 131402802-45-2Toll-like Receptor (TLR)HBVIFNARInterleukin RelatedHepatitis B virusInterferon-α/β receptorInterferon-alpha/beta receptor ILAgonisthPBMCcynomolgus monkeysAAV-HBV infectionhepatitis B virusInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
TLR7/8 agonist 13
目录号：
HY-177300
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z