2. NF-κB Immunology/Inflammation Apoptosis
  3. IKK Interleukin Related TNF Receptor RIP kinase
  4. TNF-α-IN-19

TNF-α-IN-19 是一种 TNFα 的抑制剂，可阻止 TNFαRI，TRADD 和 RIP1 的相互作用，对 TNFα，IL-1β，IL-1β/TNFα 的 EC50 分别为 2.451，3.792，1.54 μM。TNF-α-IN-19 仅在细胞受 TNFα 而非 IL-1β 刺激时才抑制 IκBα 的降解。

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TNF-α-IN-19

TNF-α-IN-19 Chemical Structure

CAS No. : 338773-13-0

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规格 价格 是否有货 数量
1 mg ￥1291
3 - 4 周
5 mg ￥3872
3 - 4 周
10 mg 询价 3 - 4 周
25 mg 询价 3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

TNF-α-IN-19 相关抗体

Top Publications Citing Use of Products

查看 IKK 亚型特异性产品:

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IKK-α IKK-β IKK IKKε TBK1

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 RIP kinase 亚型特异性产品:

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RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β[1].

IC50 & Target

IL-1β

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
2008 IC50
2.5 μM
Compound: 7, LQ011
Cytotoxicity against human cDDP-sensitive 2008 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-sensitive 2008 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
[PMID: 20951595]
A2780 IC50
2.3 μM
Compound: 7, LQ011
Cytotoxicity against human cDDP-sensitive A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-sensitive A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
[PMID: 20951595]
A2780 IC50
4.7 μM
Compound: 7, LQ011
Cytotoxicity against human cDDP-resistant A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-resistant A2780 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
[PMID: 20951595]
C13 IC50
3.4 μM
Compound: 7, LQ011
Cytotoxicity against human cDDP-resistant C13 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against human cDDP-resistant C13 cells after 72 hrs using crystal violet staining by spectrophotometric analysis
[PMID: 20951595]
Vero IC50
1.2 μM
Compound: 7, LQ011
Cytotoxicity against african green monkey Vero cells after 72 hrs using crystal violet staining by spectrophotometric analysis
Cytotoxicity against african green monkey Vero cells after 72 hrs using crystal violet staining by spectrophotometric analysis
[PMID: 20951595]
分子量

348.71

Formula

C16H8ClF3N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNF-α-IN-19 相关分类

  • 摩尔计算器

  • 稀释计算器

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNF-α-IN-19338773-13-0IKKInterleukin RelatedTNF ReceptorRIP kinaseIκB kinaseI kappa B kinase ILTumor Necrosis Factor ReceptorTNFRReceptor-interacting protein kinasesRIPKTNFαIκBαIL-1βInhibitorinhibitorinhibit

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