2. NF-κB
  3. NF-κB
  4. TNIK-IN-9

TNIK-IN-9 (Compound 54) 是一种具有选择性的、有效的 NIK 抑制剂，IC50 为 1.27 nM。TNIK-IN-9 可以抑制促炎细胞因子和一氧化氮的产生。TNIK-IN-9 在脓毒症模型中表现出显著的抗炎作用、降低死亡率和保肝作用。

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TNIK-IN-9 Chemical Structure

TNIK-IN-9 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

TNIK-IN-9 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC50 of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models[1].

体外研究
(In Vitro)

TNIK-IN-9 (5 μM, 2 h) 降低 LPS 和 CD40 诱导的 RAW264.7 细胞中炎症细胞因子和趋化因子 (分别为 TNF-α、IL-6、IL-1β 和 CCL12) 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TNIK-IN-9 相关抗体:
体内研究
(In Vivo)

TNIK-IN-9 (10 mg/kg，腹腔注射，一次) 抑制 LPS 诱导小鼠炎症细胞因子 (TNF-α、IL-1β、CXCL-12、IL-6、IFN-γ) 的分泌[1]。

药代动力学分析[1]

Route Dose (mg/kg) AUClast (ng·h/mL) AUCinf (ng·h/mL) T1/2 (h) C0 (ng/mL) CL (mL/min/kg) Cmax (ng/mL) Tmax(h)
i.v. 10 3019 3021 0.741 5059 56.2 / /
i.p. 10 2525 2551 2.27 / / 1280 0.50

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS induced mice[1]
Dosage: 10 mg/kg
Administration: i.p., once time
Result: Decreased the levels of AST, ALT, and AKP.
Reduced necrosis and inflammatory cell infiltration.
Decreased the p52 protein levels and increased p100 protein levels.
分子量

487.53

Formula

C24H21N7O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TNIK-IN-9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNIK-IN-9NF-κBNuclear factor-κBNuclear factor-kappaBsepsis modelspro-inflammatory cytokinesnitric oxideanti-inflammatoryhepatoprotectivemortalityInhibitorinhibitorinhibit

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目录号：
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