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  3. Topiramate lithium

Topiramate lithium  (Synonyms: McN 4853 lithium; RWJ 17021 lithium)

目录号: HY-B0122A
产品使用指南

Topiramate (McN 4853) lithium 是一种广谱抗癫痫剂。Topiramate lithium 也是一种 GluR5 受体拮抗剂,可通过增强 GABAergic 活性,抑制 kainate/AMPA 受体,抑制钠和钙通道的电压敏感,增加钾电导并抑制 carbonic anhydrase 来产生抗癫痫作用。

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Topiramate lithium Chemical Structure

Topiramate lithium Chemical Structure

CAS No. : 488127-53-3

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生物活性

Topiramate (McN 4853) lithium is a broad-spectrum antiepileptic agent. Topiramate lithium is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].

体外研究
(In Vitro)

Topiramate lithium has been believed to be a type of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actions have been proven to include use-dependent inhibition of voltage-dependent Na+ channels in neurons, potentiation of GABA (γ-amino-butyric acid)-induced Cl- influx, and inhibitory effects on inward currents by antagonizing kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

346.30

Formula

C12H21LiNO8S

CAS 号
中文名称

托吡酯锂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Topiramate lithium
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HY-B0122A
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