2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. EGFR ADC Antibody
  4. Trastuzumab (anti-HER2)

Trastuzumab (anti-HER2)  (Synonyms: Anti-Human HER2, Humanized Antibody (PBS))

目录号: HY-P9907A 纯度: 99.72%
COA 技术支持

Trastuzumab (PBS) 是一种人源化 IgG1 单克隆抗体，其以高亲和力与 HER2 选择性结合。Trastuzumab (PBS) 可用于 HER2 阳性转移性乳腺癌和 HER2 阳性胃癌 的研究。

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CAS No. : 180288-69-1

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Customer Review

Other Forms of Trastuzumab (anti-HER2):

Trastuzumab (anti-HER2) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 49 篇科研文献

Cell Viability Assay
WB

    Trastuzumab (anti-HER2) purchased from MCE. Usage Cited in: Cell Death Dis. 2025 Mar 12;16(1):170.  [Abstract]

    Trastuzumab (100 ng/mL; 24-94 h) significantly downregulates MCL1 protein levels in HER2-amplified NCI-N87 (Fig. A) and SNU-216 (Fig. B) cells, but shows no such effect in HER2-nonamplified GCIY cells (Fig. C).

    Trastuzumab (anti-HER2) purchased from MCE. Usage Cited in: Nat Commun. 2023 Sep 14;14(1):5699.

    Trastuzumab (TZB) (3.16-1000 nM; 14 h) is cytotoxic to GBC-SD and EH-GB1 cells.

    查看 EGFR 亚型特异性产品:

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    EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Trastuzumab (PBS) is a humanized IgG1 monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab (PBS) has the potential for HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastric Cancer research.

    同型

    Human IgG1 kappa
    推荐同型对照抗体
    反应种属

    Human
    IC50 & Target

    ERBB2/HER2/CD340
    体外研究
    (In Vitro)

    用 Trastuzumab 处理过表达 HER2 的乳腺癌细胞系会导致 p27KIP1 和 Rb 相关蛋白 p130 的诱导，从而显著减少经历 S 期的细胞数量。由于 Trastuzumab 与 HER2 过表达细胞结合，在体外观察到许多其他表型变化。Trastuzumab 通过其人免疫球蛋白 G1 Fc 结构域与人体免疫系统相互作用可能会增强其抗肿瘤活性。体外研究表明，Trastuzumab 在介导抗体依赖性细胞介导的针对 HER2 过表达肿瘤靶标的细胞毒性方面非常有效[1]。Trastuzumab 由两个抗原特异性位点组成，它们结合 HER2 受体胞外结构域的近膜部分，并阻止其胞内酪氨酸激酶的激活。Trastuzumab 募集负责抗体依赖性细胞毒性的免疫效应细胞[2]。Trastuzumab IgG 的存在显著增加了对所有乳腺癌细胞系的杀伤力。Trastuzumab 诱发的 PBMC 的 ADCC 活性对 Trastuzumab 敏感 (SKBR-3) 或 Trastuzumab 耐药 (JIMT-1) 乳腺癌细胞同样很强，剂量依赖性细胞死亡在效应物/靶标处达到 50-60%，杀死比例为 60:1[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Trastuzumab (anti-HER2) 相关抗体:
    体内研究
    (In Vivo)

    小鼠异种移植模型的 Trastuzumab 处理可显著抑制肿瘤生长。当与标准细胞毒性化疗药物联合使用时，Trastuzumab 处理与单独使用任一药物相比通常具有统计学上更好的抗肿瘤疗效[1]。Trastuzumab 可显著抑制裸鼠和 SCID 小鼠肉眼可见的 JIMT-1 异种移植肿瘤的生长[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    基因 ID

    2064  [NCBI]

    Accession
    应用

    ELISA, FACS, Functional assay
    偶联物

    Unconjugated
    复溶方法

    The product can be reconstituted/diluted with sterile PBS or saline.
    分子量

    145.42 kDa

    CAS 号
    性状

    液体

    颜色

    Colorless to light yellow

    运输条件

    Shipping with dry ice.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 kappa
    Biological Activity
    • Loaded Her2/CD340 Protein, Human (Biotinylated, HEK293, His, HY-P78882) on AHC2 biosensor, can bind Trastuzumab with an affinity constant of 6.903E-10 M as determined in BLI assay.
    • Trastuzumab has a significant ADCC effect on BT474 cells in a dose-dependent manner.The EC50 for this effect is 26.36 and 32.09 ng/mL.
    • Trastuzumab has a significant ADCC effect on SK-BR-3 cells in a dose-dependent manner.The EC50 for this effect is 14.43 and 16.70 ng/mL.
    纯度 & 产品资料

    纯度: 99.72%

    COA (268 KB) SDS-PAGE (171 KB) SEC-HPLC (75 KB)

    抗体抑制剂使用指南 (1152 KB)
    参考文献

    Trastuzumab (anti-HER2) 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Trastuzumab (anti-HER2)180288-69-1Anti-Human HER2, Humanized Antibody (PBS)EGFRADC AntibodyEpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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