1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Trequinsin hydrochloride

Trequinsin hydrochloride (Synonyms: HL 725)

目录号: HY-18740A
产品使用指南

Trequinsin hydrochloride (HL 725) 是高效的血小板 CAMP 磷酸二酯酶 (PDE)的抑制剂,IC50的0.25 nM。Trequinsin hydrochloride (HL 725) 是 ADP、胶原蛋白、凝血酶和肾上腺素在体外诱导的血小板聚集的极有效抑制剂。

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Trequinsin hydrochloride Chemical Structure

Trequinsin hydrochloride Chemical Structure

CAS No. : 78416-81-6

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Description

Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of platelet CAMP phosphodiesterase (PDE), with an IC50 of 0.25 nM. Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of the aggregation of human platelets induced in vitro by ADP, collagen, thrombin and epinephrine[1][2][3].

In Vitro

Trequinsin hydrochloride exerts besides its cardiovascular and antihypertensive qualities very potent antiplatelet activities[1].
Trequinsin hydrochloride is an efficacious agonist of [Ca2+]i[3].

Cell Viability Assay[3]

Cell Line: Samples from healthy volunteer research donors with normal sperm motility parameters in agreement with World Health Organization 2010 criteria.
Concentration: 10 μM.
Incubation Time: 20 min.
Result: Caused a concentrationdependent increase in [Ca2+]i (EC50 = 6.4 μM [95% confidence interval (CI): 4.1-9.9 μM]).
Molecular Weight

441.95

Formula

C₂₄H₂₈ClN₃O₃

CAS No.

78416-81-6

SMILES

O=C(N(CCC1=C2C=C(OC)C(OC)=C1)C2=C/3)N(C)C3=N\C4=C(C)C=C(C)C=C4C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TrequinsinHL 725HL725HL-725Phosphodiesterase (PDE)Ca2+cAMPPDE3plateletADPcollagenthrombinepinephrineInhibitorinhibitorinhibit

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产品名称:
Trequinsin hydrochloride
目录号:
HY-18740A
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