2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPC5-IN-4

TRPC5-IN-4 是一种有效且安全的 TRPC 抑制剂，对 TRPC5 和 TRPC4 的 IC50 分别为 14.07 nM 和 65 nM。TRPC5-IN-4 对肝、肾细胞成分无损伤。TRPC5-IN-4 可用于慢性肾脏病的研究 (CKD)。

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TRPC5-IN-4 Chemical Structure

TRPC5-IN-4 Chemical Structure

CAS No. : 2762315-39-7

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TRPC5-IN-4 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TRPC5-IN-4 is potent and safe TRPC inhibitor with IC50 value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD)[1].

IC50 & Target[1]

TRPC5

14.07 nM (IC50)

TRPC4

65 nM (IC50)

体外研究
(In Vitro)

TRPC5-IN-4 (compound 16 g) (0.003-3 μM; 0-1000 seconds) significantly changes intracellular Ca2+ concentration in TRPC4- and TRPC5-HEK293 cells in a dose-dependent manner, and shows very weak inhibitory activity on the TRPC3 channel, no inhibitory effect on TRPC6 and TRPC7 channels[1].
TRPC5-IN-4 (1 and 10 μM; 24 hours) does not reduce the liver and kidney cells viability[1].
TRPC5-IN-4 (0.1, 0.3, 1, 3 μM; 30 minutes) concentration-dependently reduces the PS-induced podocyte rearrangement in MPC5 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TRPC5-IN-4 相关抗体:

Cell Viability Assay

Cell Line: Primary cultured hepatocytes and MPC5 cells[1]
Concentration: 1 and 10 μM
Incubation Time: 24 hours
Result: Did not reduce the cell viability, suggesting that TRPC5-IN-4 was unlikely to damage the cellular component of liver and kidney.
分子量

442.75

Formula

C18H11ClF4N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRPC5-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPC5-IN-42762315-39-7TRP ChannelTransient receptor potential channelsPyrroledioneChronic kidney diseaseMPC5 cellsPodocyte rearrangementIntracellular Ca2+Inhibitorinhibitorinhibit

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目录号：
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