2. Anti-infection
  3. Bacterial
  4. TXA497

TXA497 是一种强效的局部外用杀菌剂。TXA497 通过干扰细菌细胞分裂蛋白 FtsZ 的聚合动力学而发挥杀菌作用，而非抑菌作用。TXA497 对包括 MRSA 和 MSSA 在内的金黄色葡萄球菌菌株均表现出强效活性，MIC 值在 1.0-2.0 μg/mL 范围内。TXA497 在皮肤中的沉积量随制剂中药物浓度的增加而增加，符合菲克第一定律。TXA497 易于通过角质层的脂质途径而全身渗透性有限。TXA497 可用于局部外用型杀菌剂研究。

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TXA497

TXA497 Chemical Structure

CAS No. : 1404289-52-6

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TXA497 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TXA497 is a potent local topical bactericide. TXA497 exerts its bactericidal effect by interfering with the polymerization kinetics of the bacterial cell division protein FtsZ, rather than inhibiting it. TXA497 shows strong activity against various Staphylococcus aureus strains, including MRSA and MSSA, with an MIC value ranging from 1.0 to 2.0 μg/mL. TXA497 skin deposition is concentration-dependent in its formulation, consistent with Fick's first law. TXA497 has limited systemic permeability through the lipid pathway of the stratum corneum and is easily absorbed through this route. TXA497 can be used for research on topical bactericidal agents[1].

分子量

281.40

Formula

C18H23N3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TXA497 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TXA4971404289-52-6TXA 497TXA-497BacterialmupirocinMRSAtopical antibacterialskin depositionskin permeationInhibitorinhibitorinhibit

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