2. Protein Tyrosine Kinase/RTK
  3. c-Met/HGFR
  4. Tyrosine kinase-IN-6

Tyrosine kinase-IN-6 是一种有效且有前景的 RON 剪接变异体 抑制剂，具有抗癌和抗肿瘤作用。

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Tyrosine kinase-IN-6

Tyrosine kinase-IN-6 Chemical Structure

CAS No. : 2377507-01-0

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Tyrosine kinase-IN-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
ASPC1 GI50
0.46 μM
Compound: 15f
Antiproliferative activity against human ASPC1 cells harbouring KRAS G12D mutant and RON delta 165 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human ASPC1 cells harbouring KRAS G12D mutant and RON delta 165 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
CAPAN-1 GI50
0.55 μM
Compound: 15f
Antiproliferative activity against human CAPAN-1 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human CAPAN-1 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
HCT-15 GI50
0.29 μM
Compound: 15f
Antiproliferative activity against human HCT-15 cells harbouring KRAS G13D mutant and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human HCT-15 cells harbouring KRAS G13D mutant and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
HT-29 GI50
0.609 μM
Compound: 15f
Antiproliferative activity against human HT-29 cells harbouring wild-type KRAS and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells harbouring wild-type KRAS and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
KM12C GI50
0.007 μM
Compound: 15f
Antiproliferative activity against human KM12-C cells harbouring wild-type KRAS and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human KM12-C cells harbouring wild-type KRAS and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
LS-411N GI50
1.01 μM
Compound: 15f
Antiproliferative activity against human LS-411N cells harbouring wild-type KRAS and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human LS-411N cells harbouring wild-type KRAS and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
MIA PaCa-2 GI50
0.63 μM
Compound: 15f
Antiproliferative activity against human MIA PaCa-2 cells harbouring KRAS G12C mutant and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human MIA PaCa-2 cells harbouring KRAS G12C mutant and RON delta 160 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
PANC-03-27 GI50
7.34 μM
Compound: 15f
Antiproliferative activity against human Panc 03.27 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human Panc 03.27 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
PANC-1 GI50
2.4 μM
Compound: 15f
Antiproliferative activity against human PANC-1 cells harbouring KRAS G12D mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human PANC-1 cells harbouring KRAS G12D mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
SW-620 GI50
0.32 μM
Compound: 15f
Antiproliferative activity against human SW620 cells harbouring KRAS G12 V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human SW620 cells harbouring KRAS G12 V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
SW1417 GI50
0.32 μM
Compound: 15f
Antiproliferative activity against human SW1417 cells harbouring wild-type KRAS and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human SW1417 cells harbouring wild-type KRAS and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
SW480 GI50
0.34 μM
Compound: 15f
Antiproliferative activity against human SW480 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
Antiproliferative activity against human SW480 cells harbouring KRAS G12V mutant and RON delta 155 assessed as cell growth inhibition measured after 72 hrs by MTS assay
[PMID: 37736180]
分子量

695.73

Formula

C37H31F2N5O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tyrosine kinase-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosine kinase-IN-62377507-01-0c-Met/HGFRRON Splice VariantsanticancertumorantineoplasticInhibitorinhibitorinhibit

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产品名称：
Tyrosine kinase-IN-6
目录号：
HY-155812
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