2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. U 93385

U 93385 是一种 5-HT₁A 受体激动剂。U 93385 无明显 α₂ 肾上腺素能、D₂ 多巴胺等其他受体活性。U 93385 具有心率调节作用，可刺激迷走神经引发心动过缓。U 93385 可用于研究 5-HT₁A 受体介导的迷走神经耐受机制。

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U 93385

U 93385 Chemical Structure

CAS No. : 147145-16-2

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U 93385 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

U93385 is a 5-HT₁A receptor agonist. U93385 exhibits no significant α₂ adrenergic, D₂ dopamine, or other receptor activities. U93385 has a heart rate regulating effect, stimulating the vagus nerve to induce bradycardia. U93385 can be used to study the 5-HT₁A receptor-mediated vagal nerve tolerance mechanism[1].

IC50 & Target[2]

5-HT1A Receptor

 

体内研究
(In Vivo)

U 93385 (0.01-3 mg/kg，静脉注射，单次剂量，累积给药或静脉输注) 单次给药可使心脏下降 20-30%，但累积给药和输注不能降低脊髓猫的心率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spinal cord transection model established in cats (2.5-4 kg)[1]
Dosage: 0.3, 1.0, 3.0 mg/kg (single dose); 0.01, 0.03, 0.1, 0.3, 1.0, 3.0 mg/kg (cumulative dose); 1 mg/kg (infusion)
Administration: Intravenous injection (i.v.), single dose, cumulative administration or intravenous infusion
Result: Dose-dependently reduced bradycardia and arterial blood pressure at single dose.
Failed to lower heart rate in animals pretreated in this cumulative manner.
分子量

258.36

Formula

C16H22N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

U 93385 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U 93385147145-16-2U93385U-933855-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorSerotonin5-HTIA receptor agonistBradycardiaHeart rateVagus nerveInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-106928
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