1. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Apoptosis
  2. VEGFR Raf Apoptosis
  3. VEGFR-2/BRAF-IN-2

VEGFR-2/BRAF-IN-2 (Compound 4a) 是一种 VEGFR-2BRAF 双重抑制剂,对 VEGFR-2、BRAFV600EBRAFWTIC50 分别为 0.111、0.089 和 0.071 µM。VEGFR-2/BRAF-IN-2 诱导细胞凋亡,在 G1 期阻滞细胞周期。

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VEGFR-2/BRAF-IN-2 Chemical Structure

VEGFR-2/BRAF-IN-2 Chemical Structure

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查看 VEGFR 亚型特异性产品:

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VEGFR-2/BRAF-IN-2 (Compound 4a) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.111, 0.089 and 0.071 µM against VEGFR-2, BRAFV600E and BRAFWT, respectively. VEGFR-2/BRAF-IN-2 induces apoptosis and arrests the cell cycle mainly in the G1 phase[1].

IC50 & Target

VEGFR2

0.111 μM (IC50)

BRafV600E

0.089 μM (IC50)

BRAFWT

0.071 μM (IC50)

分子量

608.05

Formula

C26H21ClF3N5O3S2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
VEGFR-2/BRAF-IN-2
目录号:
HY-146492
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