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  2. WKYMVM-NH2 TFA

WKYMVM-NH2 TFA 

目录号: HY-P1121A
产品使用指南

WKYMVM-NH2 TFA 是有效的 N-甲酰肽受体 FPR1 和 FPRL1/2 的激动剂,同时可以激活一些白细胞效应功能,如趋化性、激活补体受体-3 及 NADPH 氧化酶。

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WKYMVM-NH2 TFA Chemical Structure

WKYMVM-NH2 TFA Chemical Structure

CAS No. : 1435781-74-0

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Description

WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2][3].

In Vitro

WKYMVM-NH2 TFA (10-1000 nM; 24 hours) induces Caco-2 cells proliferation[3].

Cell Proliferation Assay[3]

Cell Line: Caco-2 cells (the intestinal epithelial cells)
Concentration: 0 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 24 hours
Result: Induced cell proliferation.
In Vivo

WKYMVM-NH2 TFA (8 mg/kg; six times; for 5 days) ameliorates DSS-induced ulcerative colitis[3].
WKYMVM-NH2 TFA affects cytokine (IL-17, IFN-γ, IL-6, IL-1β and TNF-α) profiles in the DSS colitis model[3].

Animal Model: Six-week-old C57BL/6 mice, DSS model[3]
Dosage: 8 mg/kg
Administration: Subcutaneously injected, six subcutaneous administrations at 12-h intervals, for 5 days
Result: Attenuated the DSS-induced increase in the bleeding score and the stool score.
Molecular Weight

970.13

Formula

C₄₃H₆₂F₃N₉O₉S₂

CAS No.

1435781-74-0

Sequence Shortening

WKYMVM-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

WKYMVM-NH2OthersN-formylpeptidereceptorFPRcytokineulcerativecolitisInhibitorinhibitorinhibit

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产品名称:
WKYMVM-NH2 TFA
目录号:
HY-P1121A
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