2. Others Autophagy Anti-infection Metabolic Enzyme/Protease
  3. Atg8/LC3 Autophagy Isotope-Labeled Compounds Bacterial Atg7 Endogenous Metabolite
  4. Xylitol-13C5

Xylitol-13C5  (Synonyms: Xylite-13C5)

目录号: HY-W768347
产品使用指南 技术支持

Xylitol-13C5 (Xylite-13C5) 是 13C 标记的 Xylitol (HY-N0538)。Xylitol 可被分类为多元醇和糖醇，对癌细胞增殖具有抑制活性，可通过激活 A549 细胞的自噬信号通路 (Xylitol 处理增加 LC3-II 和 Atg5-Atg12 的表达) 来诱导 A549 自噬 (Autophagy) 和死亡。Xylitol 还可以抑制念珠菌属产生乙醛，以此降低其致癌性。在体内，Xylitol 可诱导小鼠肠道微生物群落变化，可能会增强胆固醇的积累和肝脏 ChREBP 的上调，以及减缓 B16F10 黑色素瘤 C57BL/6 小鼠模型中的肿瘤生长。

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Xylitol-<sup>13</sup>C<sub>5</sub>

Xylitol-13C5 Chemical Structure

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Xylitol-13C5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

生物活性

Xylitol-13C5 (Xylite-13C5) is the 13C-labeled Xylitol (HY-N0538). Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model[1][2][3][4].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Xylitol-13C5 相关抗体:
分子量

157.11

Formula

13C5H12O5
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Xylitol-13C5 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xylitol-13C5Xylite-13C5Atg8/LC3AutophagyIsotope-Labeled CompoundsBacterialAtg7Endogenous MetaboliteAutophagy-related 8;Inhibitorinhibitorinhibit

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