2. Anti-infection Apoptosis
  3. Bacterial Antibiotic Apoptosis
  4. 4-Epianhydrotetracycline hydrochloride

4-Epianhydrotetracycline hydrochloride 

目录号: HY-136439
产品使用指南

摩尔计算器

4-Epianhydrotetracycline hydrochloride 是 Tetracycline (HY-A0107) 的主要中间产物。4-Epianhydrotetracycline hydrochloride 对斑马鱼胚胎显示致死作用并诱导凋亡。4-Epianhydrotetracycline hydrochloride 抑制希瓦式菌属，大肠杆菌和绿脓杆菌，MIC 值分别为 2，1 和 64 mg/L。

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4-Epianhydrotetracycline hydrochloride Chemical Structure

4-Epianhydrotetracycline hydrochloride Chemical Structure

CAS No. : 4465-65-0

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4-Epianhydrotetracycline hydrochloride 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively[1].

IC50 & Target

Tetracycline

 

体外研究
(In Vitro)

4-Epianhydrotetracycline hydrochloride (0-20 mg/L;96 h) 显著提高 ROS 水平、丙二醛 (MDA) 浓度和蛋白羰基 (PC) 含量，在 5-20.0 mg/L 的浓度区间[1]。
4-Epianhydrotetracycline hydrochloride (0-20 mg/L;96 h) 剂量依赖性地影响 SOD 活性，呈先升高后降低的趋势，在 2.50 mg/L 剂量时，SOD 活性达到最大值[1]。
4-Epianhydrotetracycline hydrochloride (0-20 mg/L;96 h) 诱导细胞凋亡[1]。
4-Epianhydrotetracycline hydrochloride (0-100 mg/L) 对斑马鱼胚胎有致死作用，96 h 的 LC50 值为 29.13 mg/L[2]。
4-Epianhydrotetracycline hydrochloride 增加斑马鱼胚胎畸形，96 h 的 EC50值为 8.57 mg/L[2]。
4-Epianhydrotetracycline hydrochloride 抑制心率 (10-20 mg/L)，并表现出延迟孵化效应 (5-20.0 mg/L)[2]。
4-Epianhydrotetracycline hydrochloride (0-20 mg/L) 抑制希瓦式菌属，大肠杆菌和绿脓杆菌的 MIC 值分别为 2、1 和 64 mg/L[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-Epianhydrotetracycline hydrochloride 相关抗体:

Apoptosis Analysis[1]

Cell Line: Zebrafish embryos
Concentration: 0, 1.25, 2.5, 5, 10 and 20 mg/L
Incubation Time: 96 hours
Result: Dose-dependently induced cell apoptosis with 66.67% zebrafish embryos showed apoptosis phenomenon at a dose of 20.0 mg/L.
分子量

462.88

Formula

C22H23ClN2O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-Epianhydrotetracycline hydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Epianhydrotetracycline4465-65-0BacterialAntibioticApoptosistetracyclineapoptosisShewanellaE. coliROSMDASODzebrafish embryosmalformationInhibitorinhibitorinhibit

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