4'-Methoxy-S-trityl-L-cysteinol

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4'-Methoxy-S-trityl-L-cysteinol 是一种脊椎动物 Kinesin Spindle Protein (KSP) 的变构抑制剂。4'-Methoxy-S-trityl-L-cysteinol 通过改造三苯甲基和半胱氨酸基团，显著增强了对 NCI60 肿瘤细胞的抑制活性。其对双极纺锤体形成的 EC₅₀ 为 28 μM，表现出比母体分子和 monastrol 更强的抑制效力。

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4'-Methoxy-S-trityl-L-cysteinol Chemical Structure

CAS No. : 1338701-15-7

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规格	价格	是否有货
1 mg	￥864	3 - 4 周
5 mg	￥3152	3 - 4 周
10 mg		询价
50 mg		询价

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4'-Methoxy-S-trityl-L-cysteinol 相关产品

•相关化合物库:

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查看 Kinesin 亚型特异性产品:

查看所有亚型

Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14

生物活性
纯度 & 产品资料
参考文献

生物活性

4'-Methoxy-S-trityl-L-cysteinol is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP). 4'-Methoxy-S-trityl-L-cysteinol significantly enhances its inhibitory activity against NCI60 tumor cells by modifying the trityl and cysteine groups. Its EC50 for bipolar spindle formation is 28 μM, showing stronger inhibitory potency than the parent molecule and monastrol.

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.44 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human 786-0 cells Growth inhibition of human 786-0 cells	[PMID: 21855351]
A549	GI₅₀	0.33 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human A549 cells Growth inhibition of human A549 cells	[PMID: 21855351]
ACHN	GI₅₀	0.49 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human ACHN cells Growth inhibition of human ACHN cells	[PMID: 21855351]
CAKI-1	GI₅₀	0.45 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human Caki1 cells Growth inhibition of human Caki1 cells	[PMID: 21855351]
CCRF-CEM	GI₅₀	0.1 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human CCRF-CEM cells Growth inhibition of human CCRF-CEM cells	[PMID: 21855351]
COLO 205	GI₅₀	0.08 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human COLO205 cells Growth inhibition of human COLO205 cells	[PMID: 21855351]
EKVX	GI₅₀	0.51 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human EKVX cells Growth inhibition of human EKVX cells	[PMID: 21855351]
HCC 2998	GI₅₀	0.05 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HCC2998 cells Growth inhibition of human HCC2998 cells	[PMID: 21855351]
HCT-116	GI₅₀	0.03 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HCT116 cells Growth inhibition of human HCT116 cells	[PMID: 21855351]
HCT-15	GI₅₀	0.21 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HCT15 cells Growth inhibition of human HCT15 cells	[PMID: 21855351]
HL-60(TB)	GI₅₀	0.19 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HL-60(TB) cells Growth inhibition of human HL-60(TB) cells	[PMID: 21855351]
HOP-62	GI₅₀	0.51 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HOP62 cells Growth inhibition of human HOP62 cells	[PMID: 21855351]
HT-29	GI₅₀	0.34 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human HT-29 cells Growth inhibition of human HT-29 cells	[PMID: 21855351]
HeLa	EC₅₀	0.19 μM Compound: 5, MSTCO, NSC-747880	Inhibition of KSP in human HeLa cells assessed as bipolar spindle formation Inhibition of KSP in human HeLa cells assessed as bipolar spindle formation	[PMID: 21855351]
IGROV-1	GI₅₀	0.26 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human IGROV1 cells Growth inhibition of human IGROV1 cells	[PMID: 21855351]
K562	GI₅₀	0.06 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human K562 cells Growth inhibition of human K562 cells	[PMID: 21855351]
KM12	GI₅₀	0.22 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human KM12 cells Growth inhibition of human KM12 cells	[PMID: 21855351]
LOX IMVI	GI₅₀	0.49 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human LOXIMVI cells Growth inhibition of human LOXIMVI cells	[PMID: 21855351]
M14	GI₅₀	0.02 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human M14 cells Growth inhibition of human M14 cells	[PMID: 21855351]
MOLT-4	GI₅₀	0.28 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human MOLT4 cells Growth inhibition of human MOLT4 cells	[PMID: 21855351]
Malme-3M	GI₅₀	0.36 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human MALME-3M cells Growth inhibition of human MALME-3M cells	[PMID: 21855351]
NCI-H226	GI₅₀	2.75 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human NCI-H226 cells Growth inhibition of human NCI-H226 cells	[PMID: 21855351]
NCI-H23	GI₅₀	0.26 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human NCI-H23 cells Growth inhibition of human NCI-H23 cells	[PMID: 21855351]
NCI-H322M	GI₅₀	0.11 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human NCI-H322M cells Growth inhibition of human NCI-H322M cells	[PMID: 21855351]
NCI-H522	GI₅₀	0.22 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human NCI-H522 cells Growth inhibition of human NCI-H522 cells	[PMID: 21855351]
OVCAR-3	GI₅₀	0.2 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human OVCAR3 cells Growth inhibition of human OVCAR3 cells	[PMID: 21855351]
OVCAR-4	GI₅₀	1.62 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human OVCAR4 cells Growth inhibition of human OVCAR4 cells	[PMID: 21855351]
OVCAR-5	GI₅₀	0.39 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human OVCAR5 cells Growth inhibition of human OVCAR5 cells	[PMID: 21855351]
OVCAR-8	GI₅₀	0.42 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human OVCAR8 cells Growth inhibition of human OVCAR8 cells	[PMID: 21855351]
SF-268	GI₅₀	0.11 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SF268 cells Growth inhibition of human SF268 cells	[PMID: 21855351]
SF-295	GI₅₀	0.28 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SF295 cells Growth inhibition of human SF295 cells	[PMID: 21855351]
SF-539	GI₅₀	0.26 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SF539 cells Growth inhibition of human SF539 cells	[PMID: 21855351]
SK-MEL-2	GI₅₀	0.24 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SK-MEL-2 cells Growth inhibition of human SK-MEL-2 cells	[PMID: 21855351]
SK-MEL-28	GI₅₀	0.62 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SK-MEL-28 cells Growth inhibition of human SK-MEL-28 cells	[PMID: 21855351]
SK-MEL-5	GI₅₀	0.06 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SK-MEL-5 cells Growth inhibition of human SK-MEL-5 cells	[PMID: 21855351]
SK-OV-3	GI₅₀	0.08 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SKOV3 cells Growth inhibition of human SKOV3 cells	[PMID: 21855351]
SN12C	GI₅₀	0.32 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SN12C cells Growth inhibition of human SN12C cells	[PMID: 21855351]
SNB-19	GI₅₀	0.25 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SNB19 cells Growth inhibition of human SNB19 cells	[PMID: 21855351]
SNB-75	GI₅₀	0.26 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SNB75 cells Growth inhibition of human SNB75 cells	[PMID: 21855351]
SR	GI₅₀	0.01 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SR cells Growth inhibition of human SR cells	[PMID: 21855351]
SW-620	GI₅₀	0.07 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human SW620 cells Growth inhibition of human SW620 cells	[PMID: 21855351]
TK-10	GI₅₀	0.46 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human TK10 cells Growth inhibition of human TK10 cells	[PMID: 21855351]
U-251	GI₅₀	0.19 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human U251 cells Growth inhibition of human U251 cells	[PMID: 21855351]
UACC-257	GI₅₀	0.54 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human UACC257 cells Growth inhibition of human UACC257 cells	[PMID: 21855351]
UACC-62	GI₅₀	0.25 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human UACC62 cells Growth inhibition of human UACC62 cells	[PMID: 21855351]
UO-31	GI₅₀	1.1 μM Compound: 5, MSTCO, NSC-747880	Growth inhibition of human UO31 cells Growth inhibition of human UO31 cells	[PMID: 21855351]

分子量

379.52

Formula

C₂₃H₂₅NO₂S

CAS 号

1338701-15-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity

4'-Methoxy-S-trityl-L-cysteinol 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4'-Methoxy-S-trityl-L-cysteinol1338701-15-7KinesinInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

4'-Methoxy-S-trityl-L-cysteinol