1. Membrane Transporter/Ion Channel
    Anti-infection
    Apoptosis
  2. Sodium Channel
    HIV
    Apoptosis
  3. 5-(N,N-Hexamethylene)-amiloride

5-(N,N-Hexamethylene)-amiloride (Synonyms: Hexamethylene amiloride; HMA)

目录号: HY-128067 纯度: >98.0%
产品使用指南

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride),是 amiloride 的衍生物,也是一种有效的 Na+/H+ 交换抑制剂,降低白血病细胞的细胞内 pH (pHi) 并诱导其凋亡。5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) 也是一种 HIV-1 Vpu 病毒离子通道抑制剂,抑制培养在 L929 细胞中的小鼠肝炎病毒 (MHV) 复制和人冠状病毒 229E (HCoV229E) 复制,EC50 值分别为 3.91 μM 和 1.34 μM。

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5-(N,N-Hexamethylene)-amiloride Chemical Structure

5-(N,N-Hexamethylene)-amiloride Chemical Structure

CAS No. : 1428-95-1

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Description

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2].

IC50 & Target

Na+/H+ exchanger[1]
EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2]

Clinical Trial
Molecular Weight

311.77

Formula

C₁₂H₁₈ClN₇O

CAS No.

1428-95-1

SMILES

O=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
5-(N,N-Hexamethylene)-amiloride
目录号:
HY-128067
需求量:

5-(N,N-Hexamethylene)-amiloride

Cat. No.: HY-128067