1. Others
  2. Others
  3. 680C91

680C91 是一种口服有效的,选择性色氨酸 2,3-双加氧酶 (TDO) 抑制剂,Ki 为 51 nM。TDO 是色氨酸分解代谢的关键酶。680C91 可用于肿瘤免疫和阿尔茨海默症的研究。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

680C91 Chemical Structure

680C91 Chemical Structure

CAS No. : 163239-22-3

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥990
In-stock
1 mg ¥342
In-stock
5 mg ¥650
In-stock
10 mg ¥1050
In-stock
25 mg ¥2050
In-stock
50 mg ¥3300
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

680C91 is an orally active, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with a Ki of 51 nM. TDO is the key enzyme of tryptophan catabolism. 680C91 can be used for the research of cancer immunotherapy and Alzheimer’s Disease[1][2][3][4].

体外研究
(In Vitro)

680C91 is a potent (Ki=51 nM) and selective TDO inhibitor with no inhibitory activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake and 5-HT1A,1D,2A and 2C receptors at a concentration of 10 μM[2].
680C91 inhibits the catabolism of tryptophan by rat liver cells and rat liver perfused in situ[2].
Tdo2 could regulate cell proliferation and stimulate the expression of decidual marker Dtprp in the uterine stromal cells and decidual cells. Tdo2 inhibitor 680C91 also inhibits the prolifer ation activity of uterine decidual cells at 24 h[3].
Treatment of leiomyoma smooth muscle cell (LSMC) and myometrial smooth muscle cell (MSMC) spheroids with 680C91 (25 and 50 μM) significantly represses the expression of collagen type I (COL1A1) and type III (COL3A1) in a dose-dependent manner[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: Uterine stromal cells
Concentration: 0.01, 0.05, 0.1, 0.5, 1, 5, and 10 μM
Incubation Time: 24 hours
Result: The proliferation activity of stromal cells was significantly decreased at 5 and 10 μM.

Western Blot Analysis[4]

Cell Line: MSMC and LSMC
Concentration: 25 and 50 μM
Incubation Time: 48 hours
Result: Significantly reduced the expression of COL1A1 and COL3A1 in LSMC spheroids with no significant effect on expression of these proteins in MSMC spheroids.
体内研究
(In Vivo)

680C91 (a dose of 15 mg/kg for acute treatment ) elevates tryptophan in brain[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl6/NCrl mice aged 13-18 weeks[5]
Dosage: 15 mg/kg
Administration: Administered per os
Result: Caused a significant increase in brain tryptophan.
分子量

238.26

Formula

C15H11FN2

CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (524.64 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.1971 mL 20.9855 mL 41.9710 mL
5 mM 0.8394 mL 4.1971 mL 8.3942 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

680C91 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1971 mL 20.9855 mL 41.9710 mL 104.9274 mL
5 mM 0.8394 mL 4.1971 mL 8.3942 mL 20.9855 mL
10 mM 0.4197 mL 2.0985 mL 4.1971 mL 10.4927 mL
15 mM 0.2798 mL 1.3990 mL 2.7981 mL 6.9952 mL
20 mM 0.2099 mL 1.0493 mL 2.0985 mL 5.2464 mL
25 mM 0.1679 mL 0.8394 mL 1.6788 mL 4.1971 mL
30 mM 0.1399 mL 0.6995 mL 1.3990 mL 3.4976 mL
40 mM 0.1049 mL 0.5246 mL 1.0493 mL 2.6232 mL
50 mM 0.0839 mL 0.4197 mL 0.8394 mL 2.0985 mL
60 mM 0.0700 mL 0.3498 mL 0.6995 mL 1.7488 mL
80 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3116 mL
100 mM 0.0420 mL 0.2099 mL 0.4197 mL 1.0493 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
680C91
目录号:
HY-108681
需求量: