2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. 6H05

6H05是突变型原癌基因K-ras(G12C)选择性变构抑制剂。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 6H05 TFA 通常具有更好的水溶性和稳定性。

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6H05 Chemical Structure

6H05 Chemical Structure

CAS No. : 1469338-01-9

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规格 是否有货
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6H05 的其他形式现货产品:

Other Forms of 6H05:

6H05 相关抗体

Top Publications Citing Use of Products

查看 Ras 亚型特异性产品:

查看所有亚型
K-Ras H-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value: Target: K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

IC50 & Target[1]

K-Ras(G12C)

 

分子量

476.12

Formula

C20H30ClN3O2S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

6H05 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6H051469338-01-9RasInhibitorinhibitorinhibit

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产品名称：
6H05
目录号：
HY-12408
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