2. Epigenetics TGF-beta/Smad
  3. PKC
  4. 7-Oxostaurosporine

7-Oxostaurosporine 是一种有效的蛋白激酶 C (PKC) 抑制剂，可通过诱导细胞凋亡(apoptosis) 和抑制核因子 (NF)-κB/p-p65 通路有效抑制肿瘤生长。

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7-Oxostaurosporine Chemical Structure

7-Oxostaurosporine Chemical Structure

CAS No. : 125035-83-8

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规格 价格 是否有货 数量
1 mg ￥6847
3 - 4 周
5 mg   询价  
10 mg   询价  

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7-Oxostaurosporine 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway[1][2].

体外研究
(In Vitro)

7-Oxostaurosporine (50 nM, 24 h)可以导致 CHO 细胞中质膜鞘磷脂增加，但不会改变神经酰胺含量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

7-Oxostaurosporine 相关抗体:
体内研究
(In Vivo)

7-Oxostaurosporin（6 mg/kg，每天一次，静脉注射）显着降低肿瘤生长，肿瘤生长抑制（TGI）为 56.1%，对体重无明显影响[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

480.51

Formula

C28H24N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

7-Oxostaurosporine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Oxostaurosporine125035-83-8PKCProtein kinase CapoptosisNF-κBp65tumorInhibitorinhibitorinhibit

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产品名称：
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目录号：
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