Haloperidol hydrochloride (Synonyms: 氟哌啶醇盐酸盐)

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Data Sheet 产品使用指南

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Haloperidol hydrochloride 是有效的 dopamine D2 receptor 拮抗剂，为一种安定药。

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Haloperidol hydrochloride Chemical Structure

CAS No. : 1511-16-6

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Haloperidol hydrochloride 的其他形式现货产品:

Haloperidol Haloperidol-d₄-1

Other Forms of Haloperidol hydrochloride:

MCE 顾客使用本产品发表的 14 篇科研文献

Haloperidol hydrochloride 相关产品

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

体内研究
(In Vivo)

Haloperidol (1 mg) intra-arterially attenuates the dopamine-induced pancreatic secretion. Haloperidol (3 mg) completely inhibits the action of 10 μg of dopamine in the pancreas of the dogs^[1]. Haloperidol (10 mg/kg) as well as chlorpromazine (CPZ, 15 mg/kg) blocks mescaline-induced altered behavior within 7 to 10 minutes when injected into the mice 45 minutes after 50 mg/kg (2 µc) of mescaline. Haloperidol has no effect on mescaline disappearance^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

412.33

Formula

C₂₁H₂₄Cl₂FNO₂

CAS 号

1511-16-6

中文名称

氟哌啶醇盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Joy CB, et al. Haloperidol versus placebo for schizophrenia. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003082. [Content Brief]

[2]. Giannini AJ, et al. Acute ketamine intoxication treated by haloperidol: a preliminary study. Am J Ther. 2000 Nov;7(6):389-91. [Content Brief]

Animal Administration ^[2]	Male albino mice of Swiss-Webster strain (33-36 g) are used, and all substances are given by i.p. injection in a volume of 0.5 mL. CPZ, haloperidoi and mescaline are all in time form of timeir imydrochlorides and the dose solutions are prepared at concentrations of 1.0, 0.66 and 3.3 mg/mL of 0.9% saline, respectively. The doses are: CPZ, 15 mg/kg; haloperidol, 10 mg/kg; mescaline, 50 mg/kg. Mice are pretreated with either CPZ or haloperidol 30 minutes before administration of mescaline. In some instances CPZ is injected 45 minutes after mescaline. Time animals are hmoused individually in a plexiglas cage and the gross behavior and locomotor activity. At selected intervals after mescaline, groups of mice are sacrificed by decapitation. Plasma is separated and stored at -20°C. The brain, liver, kidney, lung, spleen and heart are frozen on dry ice and stored at -20°C for 18 to 20 hours before they are used for assays. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Joy CB, et al. Haloperidol versus placebo for schizophrenia. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003082. [Content Brief] [2]. Giannini AJ, et al. Acute ketamine intoxication treated by haloperidol: a preliminary study. Am J Ther. 2000 Nov;7(6):389-91. [Content Brief]

Animal Administration
^[2]

Male albino mice of Swiss-Webster strain (33-36 g) are used, and all substances are given by i.p. injection in a volume of 0.5 mL. CPZ, haloperidoi and mescaline are all in time form of timeir imydrochlorides and the dose solutions are prepared at concentrations of 1.0, 0.66 and 3.3 mg/mL of 0.9% saline, respectively. The doses are: CPZ, 15 mg/kg; haloperidol, 10 mg/kg; mescaline, 50 mg/kg. Mice are pretreated with either CPZ or haloperidol 30 minutes before administration of mescaline. In some instances CPZ is injected 45 minutes after mescaline. Time animals are hmoused individually in a plexiglas cage and the gross behavior and locomotor activity. At selected intervals after mescaline, groups of mice are sacrificed by decapitation. Plasma is separated and stored at -20°C. The brain, liver, kidney, lung, spleen and heart are frozen on dry ice and stored at -20°C for 18 to 20 hours before they are used for assays.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Joy CB, et al. Haloperidol versus placebo for schizophrenia. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003082. [Content Brief]

[2]. Giannini AJ, et al. Acute ketamine intoxication treated by haloperidol: a preliminary study. Am J Ther. 2000 Nov;7(6):389-91. [Content Brief]

Haloperidol hydrochloride 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Haloperidol1511-16-6氟哌啶醇盐酸盐Dopamine ReceptorInhibitorinhibitorinhibit

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Haloperidol hydrochloride (Synonyms: 氟哌啶醇盐酸盐)

Other Forms of Haloperidol hydrochloride:

MCE 顾客使用本产品发表的 14 篇科研文献

Haloperidol hydrochloride 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 Dopamine Receptor 亚型特异性产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Haloperidol hydrochloride 相关分类

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The dilution calculator equation

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Haloperidol hydrochloride (Synonyms: 氟哌啶醇盐酸盐)

Other Forms of Haloperidol hydrochloride:

Haloperidol hydrochloride 相关抗体

MCE 顾客使用本产品发表的 14 篇科研文献

Haloperidol hydrochloride 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 Dopamine Receptor 亚型特异性产品:

生物活性

实验参考方法

纯度 & 产品资料

参考文献

Haloperidol hydrochloride 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

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