2. Metabolic Enzyme/Protease
  3. Thrombin
  4. Napsagatran hydrate

Napsagatran hydrate  (Synonyms: Ro 46-6240 hydrate; Ro 46-6240/010 hydrate)

目录号: HY-15759A
产品使用指南 技术支持

Napsagatran (Ro 46-6240) hydrate 是一种强效凝血酶 (thrombin) 抑制剂。Napsagatran hydrate 在体外和体内均表现出抗凝血作用。Napsagatran hydrate 可用于抗血栓相关研究[1][2]。

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Napsagatran hydrate

Napsagatran hydrate Chemical Structure

CAS No. : 159668-20-9

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Other Forms of Napsagatran hydrate:

Napsagatran hydrate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Napsagatran (Ro 46-6240) hydrate is a potent thrombin inhibitor. Napsagatran hydrate exhibits anticoagulant effects in vitro and in vivo. Napsagatran hydrate can be used in antithrombotic research[1][2].

体外研究
(In Vitro)

Napsagatran (10 μg/kg/min) hydrate 可减少体外灌注室模型中富含血小板的血栓形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Napsagatran hydrate 相关抗体:
体内研究
(In Vivo)

Napsagatran (3-10 μg/kg/min) hydrate 在电损伤诱导的犬冠状动脉血栓模型中，能显著预防冠状动脉闭塞并减少冠脉内血栓形成[1]。
Napsagatran (10 μg/kg/min，静脉输注 240 分钟) hydrate 可显著降低兔子的血栓相关纤维蛋白[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand rabbits[2]
Dosage: 10 μg/kg/min
Administration: i.v., infusion for 240 minutes
Result: Showed a 1.3-fold prolongation of the prothrombin time (PT) and a 1.7-fold prolongation of the partial thromboplastin time (APTT).
Significantly reduced thrombus associated fibrin after 240 min blood flow exposure.
Showed no effects in heart rate, blood pressure, plasma fibrinogen concentrations, hematocrit and blood cell counts over time.
分子量

576.67

Formula

C26H36N6O7S
CAS 号
中文名称

奈沙加群水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Napsagatran hydrate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Napsagatran159668-20-9Ro 46-6240Ro 46-6240/010奈沙加群水合物Thrombinthrombinanticoagulantantithromboticthrombus associated fibrinInhibitorinhibitorinhibit

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