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  3. Penicillamine

Penicillamine  (Synonyms: 青霉胺; D-(-)-Penicillamine)

目录号: HY-B0300 纯度: ≥98.0%
COA 产品使用指南

Penicillamine (D-(-)-Penicillamine) 是 penicillin 的代谢降解产物,可作为重金属螯合剂使用。Penicillamine 增加游离铜,增强氧化应激。Penicillamine 通过 NO/NMDA 途径对癫痫发作起作用。Penicillamine 是一种潜在的免疫调节剂。青霉胺可用于威尔逊氏病、类风湿关节炎和半胱氨酸尿症的研究。

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Penicillamine Chemical Structure

Penicillamine Chemical Structure

CAS No. : 52-67-5

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ¥550
In-stock
100 mg ¥500
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500 mg   询价  

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine increases free copper and enhances oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria[1][2][3][4].

体外研究
(In Vitro)

Penicillamine (D-(-)-Penicillamine) (5 mg; 7 d; CD4+ and CD+ splenocytes) promotes cellular immune responses[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: CD4+ and CD+ splenocytes
Concentration: 5 mg
Incubation Time: 7 days
Result: Increased IL-4 and IFN-γ mRNA expression in response to high dose treatment and remained high in both CD4+ and CD+ splenocytes.
体内研究
(In Vivo)

Penicillamine (D-(-)-Penicillamine) (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) increases serum free copper concentration[1].
Penicillamine (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) increases ATP7A and CTR1 mRNA expression in the brain of tx mice[1].
Penicillamine (200 mg/kg; i.g.; daily, for 3, 10 and 14 d; tx mice and DL mice) induces oxidative-stress in the central nervous system[1].
Penicillamine (0.1-250 mg/kg; i.p.; once, for 90 min; male NMRI mice) has binaural phase effect on seizure[2].
Penicillamine (5 mg/kg; i.v.; daily, for 8 weeks; male BN rats) prevents the onset of autoimmunity at a low dose[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Toxic milk mutant mice (tx mice) and DL mice[1]
Dosage: 200 mg/kg
Administration: Oral gavage; daily, for 3, 10 and 14 days
Result: Increased the free copper concentrations in the tx mice serum on the 3rd day.
Animal Model: Toxic milk mutant mice (tx mice) and DL mice[1]
Dosage: 200 mg/kg
Administration: Oral gavage; daily, for 3, 10 and 14 days
Result: Increased the mRNA expression of ATP7A by 4-fold. Increased CTR1 mRNA expression by 6.9-fold in the cortex and 9.1-fold in the basal ganglia of tx mice.
Animal Model: Toxic milk mutant mice (tx mice) and DL mice[1]
Dosage: 200 mg/kg
Administration: Oral gavage; daily, for 3, 10 and 14 days
Result: Increased the concentration of MDA and decreased GSH/GSSG ratios through nitric oxide/NMDA pathways.
Animal Model: Male NMRI mice[2]
Dosage: 0.1, 0.5, 1, 10, 100, 150 and 250 mg/kg
Administration: Intraperitoneal injection; once, for 90 minutes
Result: Had anticonvulsant effects at a low dose (0.5 mg/kg) and had anticonvulsant effects at a high dose (250 mg/kg). Reversed the anti- and proconvulsant effects by acute pretreatment of L-NAME (a nonselective nitric oxide synthase inhibitor) and 7-NI (a selective neuronal nitric oxide synthase inhibitor).
Animal Model: Male BN rats[3]
Dosage: 5 mg/kg
Administration: Intravenous injection; daily, for 8 weeks
Result: Inhibited IgE upregulation and prevented the onset of autoimmunity.
Clinical Trial
分子量

149.21

Formula

C5H11NO2S

CAS 号
性状

固体

颜色

White to off-white

中文名称

青霉胺

结构分类
初始来源

Penicillium

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

H2O 中的溶解度 : 83.33 mg/mL (558.47 mM; 超声助溶 (<60°C))

DMSO 中的溶解度 : 1.43 mg/mL (9.58 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 6.7020 mL 33.5098 mL 67.0196 mL
5 mM 1.3404 mL 6.7020 mL 13.4039 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (670.20 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 6.7020 mL 33.5098 mL 67.0196 mL 167.5491 mL
5 mM 1.3404 mL 6.7020 mL 13.4039 mL 33.5098 mL
H2O 10 mM 0.6702 mL 3.3510 mL 6.7020 mL 16.7549 mL
15 mM 0.4468 mL 2.2340 mL 4.4680 mL 11.1699 mL
20 mM 0.3351 mL 1.6755 mL 3.3510 mL 8.3775 mL
25 mM 0.2681 mL 1.3404 mL 2.6808 mL 6.7020 mL
30 mM 0.2234 mL 1.1170 mL 2.2340 mL 5.5850 mL
40 mM 0.1675 mL 0.8377 mL 1.6755 mL 4.1887 mL
50 mM 0.1340 mL 0.6702 mL 1.3404 mL 3.3510 mL
60 mM 0.1117 mL 0.5585 mL 1.1170 mL 2.7925 mL
80 mM 0.0838 mL 0.4189 mL 0.8377 mL 2.0944 mL
100 mM 0.0670 mL 0.3351 mL 0.6702 mL 1.6755 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Penicillamine
目录号:
HY-B0300
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