1. Anti-infection
  2. Bacterial Antibiotic
  3. Polymyxin B Sulfate

Polymyxin B Sulfate  (Synonyms: 硫酸多粘菌素 B)

目录号: HY-A0248 纯度: 96.88%
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Polymyxin B Sulfate 是一种有效的抗菌剂和相对有毒的抗生素。Polymyxin B Sulfate 也是一种抗内毒素剂。Polymyxin B Sulfate 显示出内毒素中和特性,可用作革兰氏阴性脓毒症的辅助研究。Polymyxin B Sulfate 在体外和体内均显示出抗菌活性。

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Custom Peptide Synthesis

Polymyxin B Sulfate

Polymyxin B Sulfate Chemical Structure

CAS No. : 1405-20-5

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Other Forms of Polymyxin B Sulfate:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo[1][2][3].

体外研究
(In Vitro)

Polymyxin B Sulfate 对 E. coli IH3080 表现抗菌活性,MIC 为 0.5 mg/L[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

多粘菌素 B 硫酸盐(0.5-120 mg/kg;皮下注射)在小鼠大腿或肺部感染模型中表现出抗菌活性[2][1234]多粘菌素 B 硫酸盐(2 mg/kg,皮下注射)对小鼠大肠杆菌菌株 IH3080表现出强效杀菌作用>[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old, 24-30 g, female Swiss mice[2]
Dosage: 0.5-120 mg/kg for thigh infection model; 5-120 mg/kg for lung infection mode
Administration: S.c.
Result: Showed antibacterial activities for three K. pneumoniae strains.
Animal Model: 7-9 weeks, female NMRI mice (E. coli IH3080)[3]
Dosage: 2 mg/kg
Administration: S.c.
Result: Decreased the bacterial count in a dose dependent manner.
分子量

1199.75 (average)

CAS 号
性状

固体

颜色

White to off-white

中文名称

硫酸多粘菌素 B;多粘菌素 B 硫酸酯;硫酸阿罗多粘;硫酸多粘菌素 B;托吡卡胺硫酸多粘菌素B;多粘菌素B 硫酸盐;硫酸多粘B

结构分类
初始来源

Bacillus polymyxa

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

H2O 中的溶解度 : 125 mg/mL (超声助溶)

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 96.88%

参考文献
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Polymyxin B Sulfate
目录号:
HY-A0248
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