2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. Protease-Activated Receptor-2, amide

Protease-Activated Receptor-2, amide  (Synonyms: 蛋白酶活化的受体-2，酰胺)

目录号: HY-P0283 纯度: 99.33%
COA 产品使用指南

摩尔计算器

Protease-Activated Receptor-2, amide (SLIGKV-NH2) 是一种高效的蛋白酶活化受体-2 (PAR2) 活化肽。

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Custom Peptide Synthesis

Protease-Activated Receptor-2, amide Chemical Structure

Protease-Activated Receptor-2, amide Chemical Structure

CAS No. : 190383-13-2

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥947
In-stock
1 mg ￥350
In-stock
5 mg ￥700
In-stock
10 mg ￥1200
In-stock
25 mg ￥2200
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Protease-Activated Receptor-2, amide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.

IC50 & Target

PAR2[1]
体外研究
(In Vitro)

The PAR2-activating peptides used are: SLIGKV-OH, SLIGRL-OH, SLIGKV-NH2, SLIGRL-NH2. The synthetic agonist peptides mimicking the tethered ligand of PAR2, Ser-Leu-Ile-Gly-Lys-Val (SLIGKV-OH), Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL-OH) and their amidated forms Ser-Leu-Ile-Gly-Lys-Val-amide (SLIGKV-NH2) Ser-Leu-Ile-Gly-Arg-Leu-amide (SLIGRL-NH2) have also been demonstrated being able to activate the receptor without enzymatic cleavage, therefore, have been utilised as biological tools to examine physiological functions of PAR2. Protease-Activated Receptor-2, amide is one of a four family subgroup of G-protein-coupled receptors (GPCRs), called PARs. Protease-activated receptors are distinguished from other GPCRs through their unique proteolytic mechanism of activation. For PAR2, activating proteases, such as trypsin, tryptase and coagulation factors VIIa and Xa, cleave a specific extracellular amino-terminal domain of the receptor to reveal a "tethered ligand", SLIGKV- and SLIGRL- for human and mouse/rat PAR2, respectively, which subsequently interacts with the activation domain of the receptor, initiating intracellular signaling pathways[1]. The protease-activated receptor-2 (PAR2) has been implicated in the pathogenesis of several inflammatory and autoimmune disorders, and is expressed in a wide variety of human tissues and cells. PAR2 belongs to a family of seven transmembrane domain receptor proteins that are activated by proteolysis. Enzymatic digestion exposes an N-terminus ligand sequence that binds intramolecularly to the activation site on the extracellular loop II, initiating a G-protein-mediated cell-signalling cascade and nuclear factor-kappa B (NF-κB)-regulated gene transcription[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Protease-Activated Receptor-2, amide 相关抗体:
分子量

614.78

Formula

C28H54N8O7
CAS 号
性状

固体

颜色

White to off-white

Sequence

Ser-Leu-Ile-Gly-Lys-Val-NH2
Sequence Shortening

SLIGKV-NH2
中文名称

蛋白酶活化的受体-2，酰胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 33.33 mg/mL (54.21 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6266 mL 8.1330 mL 16.2660 mL
5 mM 0.3253 mL 1.6266 mL 3.2532 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 100 mg/mL (162.66 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Protease-Activated Receptor-2, amide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6266 mL 8.1330 mL 16.2660 mL 40.6650 mL
5 mM 0.3253 mL 1.6266 mL 3.2532 mL 8.1330 mL
10 mM 0.1627 mL 0.8133 mL 1.6266 mL 4.0665 mL
15 mM 0.1084 mL 0.5422 mL 1.0844 mL 2.7110 mL
20 mM 0.0813 mL 0.4066 mL 0.8133 mL 2.0332 mL
25 mM 0.0651 mL 0.3253 mL 0.6506 mL 1.6266 mL
30 mM 0.0542 mL 0.2711 mL 0.5422 mL 1.3555 mL
40 mM 0.0407 mL 0.2033 mL 0.4066 mL 1.0166 mL
50 mM 0.0325 mL 0.1627 mL 0.3253 mL 0.8133 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Protease-Activated Receptor-2, amide190383-13-2蛋白酶活化的受体-2，酰胺Protease Activated Receptor (PAR)Thrombin receptorsInhibitorinhibitorinhibit

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