1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Ro 10-5824 dihydrochloride

Ro 10-5824 dihydrochloride 

目录号: HY-101384A 纯度: 99.93%
COA 产品使用指南

Ro 10-5824 dihydrochloride 是一种选择性的 dopamine D4 受体 部分激动剂,Ki 值为 5.2 nM。

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Ro 10-5824 dihydrochloride Chemical Structure

Ro 10-5824 dihydrochloride Chemical Structure

CAS No. : 189744-94-3

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Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ¥880
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5 mg ¥800
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10 mg ¥1200
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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.

IC50 & Target

Ki: 5.2 nM (dopamine D4 receptor)[2]

体外研究
(In Vitro)

RO-10-5824 shows high affinity binding with a Ki=5.2±0.9 nM (n=3), 250-fold selectivity vs human D3R, and >1000 fold selectivity for D4 vs human D2, D1, and D5 receptors. RO-10-5824 stimulates 35S-GTPγS binding with an EC50 value of 205±67 nM (n=7) and maximal induction at 36±4% above basal level[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ro 10-5824 (3 mg/kg) increases the success rate in the ORD task. At doses of 1 and 3 mg/kg, Ro 10-5824 increases baseline gamma band activity in the frontal cortex. Ro 10-5824 has no effect on spontaneous locomotion[1]. RO-10-5824 (10.0 mg/kg) does not increase center entries in the open field in a single 60-min session without the novel object present, nor does it increase overall transitions in the initial experiment with C57 mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

353.29

Formula

C17H22Cl2N4

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 100 mg/mL (283.05 mM; 超声助溶)

DMSO 中的溶解度 : 8.33 mg/mL (23.58 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8305 mL 14.1527 mL 28.3054 mL
5 mM 0.5661 mL 2.8305 mL 5.6611 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案,请直接配置工作液。建议现用现配,在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比; 如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂: PBS

    Solubility: 50 mg/mL (141.53 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Animal Administration
[2]

In the experiment, 39 C57 and 40 DBA mice are tested over a three-day period. On days 1 and 2, mice are placed into the VT for 60 min and locomotor behavior is recorded. On the third day, mice are placed into the VT chamber for 60 min. Following the 60-min period, mice are removed from the chambers and administered 0, 1.0, 3.0, or 10.0 mg/kg of RO-10-5824 (n=9-11 per group). Mice are assigned to drug group pseudo-randomly, with each dose being represented in a cage of four mice. A novel paper cup measuring 9.5 cm in height and 7.5 cm in diameter at the rim is placed upside down in the center of each open field and secured to the floor with tape. Mice are returned to the VT 10 min following injection and tested for an additional 30 min.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

Ro 10-5824 dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.8305 mL 14.1527 mL 28.3054 mL 70.7634 mL
5 mM 0.5661 mL 2.8305 mL 5.6611 mL 14.1527 mL
10 mM 0.2831 mL 1.4153 mL 2.8305 mL 7.0763 mL
15 mM 0.1887 mL 0.9435 mL 1.8870 mL 4.7176 mL
20 mM 0.1415 mL 0.7076 mL 1.4153 mL 3.5382 mL
H2O 25 mM 0.1132 mL 0.5661 mL 1.1322 mL 2.8305 mL
30 mM 0.0944 mL 0.4718 mL 0.9435 mL 2.3588 mL
40 mM 0.0708 mL 0.3538 mL 0.7076 mL 1.7691 mL
50 mM 0.0566 mL 0.2831 mL 0.5661 mL 1.4153 mL
60 mM 0.0472 mL 0.2359 mL 0.4718 mL 1.1794 mL
80 mM 0.0354 mL 0.1769 mL 0.3538 mL 0.8845 mL
100 mM 0.0283 mL 0.1415 mL 0.2831 mL 0.7076 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ro 10-5824 dihydrochloride
目录号:
HY-101384A
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