TTNPB (Synonyms: Ro 13-7410; Arotinoid acid; AGN191183)

目录号: HY-15682 纯度: 99.85%: Data Sheet SDS COA 产品使用指南
FAQs
技术支持

TTNPB 是一种有效的 RAR 激动剂。使用人RARs进行竞争性结合实验中，作用于 RARα，RARβ 和 RARγ，IC₅₀ 分别为 5.1 nM，4.5 nM 和 9.3 nM。

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TTNPB Chemical Structure

CAS No. : 71441-28-6

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规格	价格	是否有货
10 mM * 1 mL in DMSO	￥880	In-stock
1 mg	￥274	In-stock
5 mg	￥800	In-stock
10 mg	￥1160	In-stock
25 mg	￥2281	In-stock
50 mg	￥3650	In-stock
100 mg	￥5110	In-stock
200 mg		询价
500 mg		询价

or 大包装询价

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Customer Review

Other Forms of TTNPB:

TTNPB (GMP) 询价
TTNPB (Standard) 询价

MCE 顾客使用本产品发表的 4 篇科研文献

TTNPB 相关产品

•相关化合物库:

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RXRα RXRβ RXRγ

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC₅₀s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.

IC₅₀ & Target

IC50: 5.1 nM (RARα), 4.5 nM (RARβ), 9.3 nM (RARγ)^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
F9	ED₅₀	0.08 nM Compound: 2	Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay Ability to displace 3 uM retinoid and [3H]all-trans-retinoic acid in F9 embryonal carcinoma cells using F9 Plasminogen Activator releasing assay	[PMID: 2738885]
HEK293	EC₅₀	0.18 nM Compound: TTNPB	Agonist activity at human RARalpha expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at human RARalpha expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25305688]

体外研究
(In Vitro)

TTNPB 抑制 [³H]tRA 的结合，对人 RARα、β 和 γ 的 IC₅₀ 分别为 3.8 nM、4 nM 和 4.5 nM。TTNPB 竞争 [³H]tRA 与 CRABPI 的结合，IC₅₀ 为 1800 nM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

348.48

Formula

C₂₄H₂₈O₂

CAS 号

71441-28-6

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

细胞实验：

DMSO 中的溶解度 : 8.33 mg/mL (23.90 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8696 mL	14.3480 mL	28.6961 mL
5 mM	0.5739 mL	2.8696 mL	5.7392 mL
10 mM	0.2870 mL	1.4348 mL	2.8696 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.85%

选择批次：

Data Sheet (602 KB) SDS (644 KB)

COA (284 KB) HNMR (135 KB) LCMS (94 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142(2):319-27. [Content Brief]

Kinase Assay ^[1]	Labeled and unlabeled retinoids are added to nucleosol or cytosolic fractions in ethanol so that the total amount of ethanol added is constant in all tubes and did not exceed 2% of the incubation volume. The receptor preparations are incubated with retinoids at 47°C for 4-6 hr. Sephadex PD-10 desalting columns are used to separate bound radioligand from free radioligand after equilibrium is achieved. For competitive binding assays, varying concentrations of unlabeled competing ligand are incubated with the appropriate nucleosol or cytosol in the presence of a fixed concentration of [³H]tRA (sp act. 49.3 Ci/mmol) or [³H]9-cis RA (sp. act. 24.0 Ci/mmol). Final concentrations of [³H] tRA and [³H]9-cis RA for nuclear receptor binding assays are 5nM. Final concentrations of [³H]tRA for CRABP binding assays is 30 nM. The IC₅₀s are calculated. For saturation kinetics, increasing concentrations of radiolabeled ligand ([³H]tRA sp. act. 49.3 Ci/mmol, [³H]TTNPB sp. act. 5.5 Ci/mmol) are added to the nucleosol of the appropriate receptor subtype in the presence (nonspecific binding) or absence (total binding) of a 100-fold molar excess of the corresponding unlabeled retinoid. Specific binding is defined as the total binding minus nonspecific binding. Saturation kinetics are calculated^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142(2):319-27. [Content Brief]

Kinase Assay
^[1]

Labeled and unlabeled retinoids are added to nucleosol or cytosolic fractions in ethanol so that the total amount of ethanol added is constant in all tubes and did not exceed 2% of the incubation volume. The receptor preparations are incubated with retinoids at 47°C for 4-6 hr. Sephadex PD-10 desalting columns are used to separate bound radioligand from free radioligand after equilibrium is achieved. For competitive binding assays, varying concentrations of unlabeled competing ligand are incubated with the appropriate nucleosol or cytosol in the presence of a fixed concentration of [³H]tRA (sp act. 49.3 Ci/mmol) or [³H]9-cis RA (sp. act. 24.0 Ci/mmol). Final concentrations of [³H] tRA and [³H]9-cis RA for nuclear receptor binding assays are 5nM. Final concentrations of [³H]tRA for CRABP binding assays is 30 nM. The IC₅₀s are calculated. For saturation kinetics, increasing concentrations of radiolabeled ligand ([³H]tRA sp. act. 49.3 Ci/mmol, [³H]TTNPB sp. act. 5.5 Ci/mmol) are added to the nucleosol of the appropriate receptor subtype in the presence (nonspecific binding) or absence (total binding) of a 100-fold molar excess of the corresponding unlabeled retinoid. Specific binding is defined as the total binding minus nonspecific binding. Saturation kinetics are calculated^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Pignatello MA, et al. Multiple factors contribute to the toxicity of the aromatic retinoid, TTNPB (Ro 13-7410): binding affinities and disposition. Toxicol Appl Pharmacol. 1997 Feb;142(2):319-27. [Content Brief]

TTNPB 相关分类

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8696 mL	14.3480 mL	28.6961 mL	71.7401 mL
	5 mM	0.5739 mL	2.8696 mL	5.7392 mL	14.3480 mL
	10 mM	0.2870 mL	1.4348 mL	2.8696 mL	7.1740 mL
	15 mM	0.1913 mL	0.9565 mL	1.9131 mL	4.7827 mL
	20 mM	0.1435 mL	0.7174 mL	1.4348 mL	3.5870 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TTNPB71441-28-6Ro 13-7410 Arotinoid acid AGN191183AGN191183AGN 191183AGN-191183RAR/RXRAutophagyApoptosisRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TTNPB (Synonyms: Ro 13-7410; Arotinoid acid; AGN191183)

Customer Review

Other Forms of TTNPB:

MCE 顾客使用本产品发表的 4 篇科研文献