2. Epigenetics TGF-beta/Smad Apoptosis
  3. PKC Apoptosis
  4. OSU-2S

OSU-2S 是一种有效的 PKCδ 激活剂。OSU-2S 抑制细胞增殖和迁移。当与 Sorafenib (HY-10201) 连用时，降低 p-ERK1/2 的表达，增加 PKCδ (38 kDa) 的表达。OSU-2S 诱导细胞凋亡 (Apoptosis)。OSU-2S slao 是 FTY720 的非免疫抑制类似物。OSU-2S 具有抗癌活性。

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OSU-2S Chemical Structure

OSU-2S Chemical Structure

CAS No. : 1351056-65-9

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OSU-2S 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OSU-2S is a potent PKCδ activator. OSU-2S inhibits cell proliferation and migration. OSU-2S decreases the expression of p-ERK1/2, increases the expression of PKCδ (38 kDa) when combined with Sorafenib (HY-10201). OSU-2S induces Apoptosis. OSU-2S slao is a non-immunosuppressive analogue of FTY720. OSU-2S shows anticancer activity[1][2].

IC50 & Target[1]

PKCδ

 

体外研究
(In Vitro)

OSU-2S (1.25, 2.5 µM; 48 h) 与 Sorafenib (HY-10201) (2.5, 5 µM) 联用时，降低 p-ERK1/2 的表达，增加 PKCδ (38 kDa) 的表达[1]。
OSU-2S/Sorafenib (1.25, 2.5 µM; 8 h) 组合抑制细胞增殖和迁移[1]。
OSU-2S (0, 1, 2.5, 5 µM; 0-24 h) 以剂量和时间依赖性方式降低 Hep3B 细胞中 PARP 的表达[2]。
OSU-2S (5 µM; 12, 24 h) 诱导 Hep3B 细胞凋亡[2]。
OSU-2S (0-10 µM; 1 h) 以剂量依赖性方式刺激 Hep3B、Huh7、PLC-5 细胞中 ROS 的产生[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OSU-2S 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Hep3B, Huh7, PLC-5, HepG2 cells
Concentration: 0-10 µM
Incubation Time: 48 h
Result: Showed anti-proliferative effects with IC50s of 2.53, 2.41, 3.96, 1.84 µM for Hep3B, Huh7, PLC-5, HepG2 cells, respectively.

Western Blot Analysis[1]

Cell Line: Hep3B cells
Concentration: 1.25, 2.5 µM combinated with sorafenib (2.5, 5 µM)
Incubation Time: 48 h
Result: Decreased the expression of ERK1/2 phosphorylation, increased the expression of PKCδ (38 kDa) when sorafenib/OSU-2S combination.
体内研究
(In Vivo)

OSU-2S (5, 10 mg/kg; i.p.; once daily for 42 days) 抑制小鼠的肿瘤生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD2F1 mice (Hep3B tumor xenograft models)[2]
Dosage: 5, 10 mg/kg
Administration: I.p.; once daily for 42 days
Result: Exhibited a higher tumor-suppressive potency, achieving 80% reduction in bioluminescence at the end of treatment.
分子量

335.52

Formula

C21H37NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OSU-2S 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OSU-2S1351056-65-9PKCApoptosisProtein kinase Canti-proliferativeantimigrationanticancerHep3Bp-ERK1/2SorafenibROSapoptosisInhibitorinhibitorinhibit

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