2. NF-κB
  3. IKK
  4. TBK1/IKKε-IN-1

TBK1/IKKε-IN-1 是一种双重 TBK1 和 IKKε 抑制剂，IC50s 值 <100 nM。详细信息请参考专利文献 US20160376283 A1 中 Example 60 中的化合物 274。

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TBK1/IKKε-IN-1 Chemical Structure

TBK1/IKKε-IN-1 Chemical Structure

CAS No. : 2058264-32-5

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TBK1/IKKε-IN-1 相关抗体

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IKK-α IKK-β IKK IKKε TBK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TBK1/IKKε-IN-1 is a dual TBK1 and IKKε inhibitor extracted from patent US20160376283 A1, Compound 274 in Example 60, has IC50s of <100 nM.

IC50 & Target

TBK1

100 nM (IC50)

IKKε

100 nM (IC50)

体外研究
(In Vitro)

IKKε and TBK1 are serine/threonine kinases which are highly homologous to one another and other IkB kinases (IKK-α and IKK-β). The two kinases play an integral role in the innate immune system. Double-stranded RNA viruses are recognised by the Toll-like receptors 3 and 4 and the RNA helicases RIG-I and MDA-5 and result in activation of the TRIF-TBK1/IKKε-IRF3 signalling cascade, which results in a type I interferon response[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TBK1/IKKε-IN-1 相关抗体:
分子量

498.53

Formula

C28H26N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TBK1/IKKε-IN-1 相关分类

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  • 稀释计算器

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TBK1/IKKε-IN-12058264-32-5IKKIκB kinaseI kappa B kinaseInhibitorinhibitorinhibit

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