2. Apoptosis
  3. Caspase Apoptosis
  4. Ac-DEVD-CHO TFA

Ac-DEVD-CHO TFA 是 caspase-3 (Ki=230 pM) 和 caspase -7 的肽抑制剂。Ac-DEVD-CHO TFA 降低 Prostaglandin E2 (HY-101952) 诱导的大鼠皮质神经元 caspase-3 活性和凋亡 (apoptosis)。Ac-DEVD-CHO TFA 有望用于神经退行性疾病和癌症的研究。

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Ac-DEVD-CHO TFA

Ac-DEVD-CHO TFA Chemical Structure

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Ac-DEVD-CHO TFA 的其他形式现货产品:

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Ac-DEVD-CHO TFA 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 40 篇科研文献

WB

    Ac-DEVD-CHO TFA purchased from MCE. Usage Cited in: Apoptosis. 2019 Oct;24(9-10):703-717.  [Abstract]

    BMDMs were first primed with LPS (500 ng/ml) for 4 h, pre-treated with or without MCC950 (1 μM) and caspase-3 inhibitor Ac-DEVD-CHO (DEVD) for 1 h and followed by stimulation with ATP (5 mM) in the presence or absence of MCC950. The cell lysates are collected and western blotting is performed to assess the expression levels of indicated proteins.

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    Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Ac-DEVD-CHO TFA is a peptide inhibitor of caspase-3 (Ki=230 pM) and caspase-7. Ac-DEVD-CHO TFA reduces caspase-3 activity and apoptosis induced by Prostaglandin E2 (HY-101952) in rat cortical neurons. Ac-DEVD-CHO TFA is promising for research of neurodegenerative diseases and cancers[1][2].

    IC50 & Target

    Caspase-3

    230 pM (Ki)

    Caspase-7

     

    分子量

    616.50

    Formula

    C22H31F3N4O13
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Ac-DEVD-CHO TFA 相关分类

    • 摩尔计算器

    • 稀释计算器

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ac-DEVD-CHOCaspaseApoptosiscaspase-3caspase-7rat cortical neuronsneurodegenerative diseases and cancersInhibitorinhibitorinhibit

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