2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. Aldometanib

Aldometanib  (Synonyms: LXY-05-029)

目录号: HY-148189 纯度: 99.73%
COA 产品使用指南

摩尔计算器

Aldometanib (LXY-05-029) 是一种醛缩酶抑制剂。Aldometanib 可以激活溶酶体腺苷-磷酸活化蛋白激酶 AMPK 并降低血糖。Aldometanib 可用于代谢稳态的研究。

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Aldometanib Chemical Structure

Aldometanib Chemical Structure

CAS No. : 2904601-67-6

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规格 价格 是否有货 数量
1 mg ￥409
In-stock
5 mg ￥900
In-stock
10 mg ￥1440
In-stock
25 mg ￥2750
In-stock
50 mg ￥4350
In-stock
100 mg ￥7000
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Aldometanib 相关抗体

Top Publications Citing Use of Products

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis[1].

体外研究
(In Vitro)

Aldometanib (0-1000 nM；2 小时) 通过阻止醛缩酶与 FBP 结合以产生假性饥饿信号来激活 AMPK[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aldometanib 相关抗体:

Western Blot Analysis[1]

Cell Line: Mouse primary hepatocytes, MEFs cells
Concentration: 0-1000 nM
Incubation Time: 2 h
Result: Activated AMPK in mouse embryonic fibroblasts (MEFs) and mouse primary hepatocytes cells.

Immunofluorescence[1]

Cell Line: MEFs cells
Concentration: 5 nM
Incubation Time: 2 h
Result: Inhibited TRPVs and induces AXIN lysosomal translocation.
体内研究
(In Vivo)

Aldometanib (oral; 0-10 mpk) 可降低瘦小鼠的血糖[1]。
Aldometanib (oral; 2-10 mpk; twice daily; for a week) 可降低血糖并减轻肥胖高血糖小鼠的脂肪肝[1]。
Aldometanib 减轻脂肪肝和非酒精性脂肪性肝炎[1]。
Aldometanib (oral; 2mpk; twice-daily; for a month) 减轻 NASH 小鼠的肝纤维化[1]。
Aldometanib (oral; 0-50 μM; 0-50 days) 可通过溶酶体途径延长 C. elegans 生命[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lean mice[1]
Dosage: 0-10 mpk
Administration: Oral
Result: Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.
Animal Model: Obese hyperglycaemic mice[1]
Dosage: 2-10 mpk
Administration: Oral, twice daily, for a week
Result: Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.
Animal Model: NASH mice[1]
Dosage: 2 mpk
Administration: Oral, twice-daily, for a month
Result: Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.
Animal Model: C. elegans[1]
Dosage: 0-50 μM
Administration: Oral, 0-50 days
Result: Promoted oxidative stress resistance and mitochondrial functions in C. elegans.
Animal Model: C57BL/6 mice[1]
Dosage: 100 μg/mL
Administration: Oral
Result: Extended lifespan, elevated NAD＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.
分子量

593.45

Formula

C27H43Cl2IN2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (168.51 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6851 mL 8.4253 mL 16.8506 mL
5 mM 0.3370 mL 1.6851 mL 3.3701 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Aldometanib 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6851 mL 8.4253 mL 16.8506 mL 42.1265 mL
5 mM 0.3370 mL 1.6851 mL 3.3701 mL 8.4253 mL
10 mM 0.1685 mL 0.8425 mL 1.6851 mL 4.2127 mL
15 mM 0.1123 mL 0.5617 mL 1.1234 mL 2.8084 mL
20 mM 0.0843 mL 0.4213 mL 0.8425 mL 2.1063 mL
25 mM 0.0674 mL 0.3370 mL 0.6740 mL 1.6851 mL
30 mM 0.0562 mL 0.2808 mL 0.5617 mL 1.4042 mL
40 mM 0.0421 mL 0.2106 mL 0.4213 mL 1.0532 mL
50 mM 0.0337 mL 0.1685 mL 0.3370 mL 0.8425 mL
60 mM 0.0281 mL 0.1404 mL 0.2808 mL 0.7021 mL
80 mM 0.0211 mL 0.1053 mL 0.2106 mL 0.5266 mL
100 mM 0.0169 mL 0.0843 mL 0.1685 mL 0.4213 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aldometanib2904601-67-6LXY-05-029AMPKAMP-activated protein kinaseoraladenosine monophosphate-activated protein kinase (AMPK)blood glucosemetabolicInhibitorinhibitorinhibit

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