2. Metabolic Enzyme/Protease Apoptosis
  3. Cytochrome P450 Glutathione Peroxidase
  4. ALT-2074

ALT-2074 (BXT-51071) 是一种具有口服活性的谷胱甘肽过氧化物酶的催化模拟物。ALT-2074 是人源 CYP3A 的抑制剂，其 IC50 值在 2.0-2.6 μM 范围内。ALT-2074 在体内对仅表现出对 CYP3A 的弱抑制作用，提示其可能不会显著影响 CYP3A 底物药物的代谢。ALT-2074 可用于研究以活性氧物种为特征的炎症性疾病，例如急性冠状动脉综合征。

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ALT-2074

ALT-2074 Chemical Structure

CAS No. : 173026-17-0

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ALT-2074 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome[1].

IC50 & Target[1]

CYP3A

2-2.6 μM (IC50)

分子量

226.18

Formula

C10H13NSe
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALT-2074 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALT-2074173026-17-0BXT-51072ALT2074ALT 2074BXT51072BXT 51072Cytochrome P450Glutathione PeroxidaseCYPsoral midazolamritonavirCYP3A inhibitiondrug interactioncytochrome P450 3Apharmacokineticsclinical studyglutathione oxidase mimiccatalytic mimicInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-W879508
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