2. Apoptosis
  3. Apoptosis
  4. Anti-CSCs agent-1

Anti-CSCs agent-1 是一种有效的抗 CSCs 剂。 Anti-CSCs agent-1 抑制细胞生长和细胞迁移。Anti-CSCs agent-1 诱导细胞凋亡 (Apoptosis)。Anti-CSCs agent-1 抑制 CSCs 的活力。Anti-CSCs agent-1 可增强 CSCs 中 ROS 的产生。Anti-CSCs agent-1 具有抗肿瘤活性。

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Anti-CSCs agent-1 Chemical Structure

Anti-CSCs agent-1 Chemical Structure

CAS No. : 2251753-58-7

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规格 价格 是否有货 数量
1 mg ￥2225
3 - 4 周
5 mg   询价  
10 mg   询价  

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Anti-CSCs agent-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-CSCs agent-1 is a potent anti-CSCs agent. Anti-CSCs agent-1 inhibits cell growth and cell migration. Anti-CSCs agent-1 induces Apoptosis. Anti-CSCs agent-1 inhibits the viability of CSCs. Anti-CSCs agent-1 enhances the production of ROS in CSCs. Anti-CSCs agent-1 shows antitumor activity[1].

体外研究
(In Vitro)

Anti-CSCs agent-1 (compound 48) (0, 0.25, 0.5 µM) 以剂量依赖性方式抑制 A375 和 B16F10 细胞的集落形成和细胞迁移[1]。
Anti-CSCs agent-1 (0, 1, 2, 3, 4 µM; 48 h) 诱导细胞凋亡，并以剂量依赖的方式增加 cleaved PARP、cleaved caspase-3、P-53 和 Bax 的表达[1].
Anti-CSCs agent-1 (0, 0.25, 0.5, 1.0, 2.0 µM; 24 h) 以剂量依赖的方式显着上调 E-cadherin 的表达来逆转上皮间质转化[1].
Anti-CSCs agent-1 (0-10 µM; 15 days) 抑制 CSCs 的活力，对球状体 A357、B16F10 细胞的 IC50 值分别为 3.04、1.24 µM[1].
Anti-CSCs agent-1 (0-2 µM; 24 h) 以剂量依赖的方式显着增加 CSCs 中的 ROS 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-CSCs agent-1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, 4T1, A375, B16F10, PANC-1, A549, LLC cells
Concentration: 0-50 µM
Incubation Time: 48 h
Result: Showed antiproliferative activity with IC50s of 3.152, 0.7401, 0.8929, 0.6744, 1.107, 11.56, 0.9066 µM for MDA-MB-231, 4T1, A375, B16F10, PANC-1, A549, LLC cells, respectively.

Apoptosis Analysis[1]

Cell Line: A375, B16F10 cells
Concentration: 0, 1, 2, 3 µM
Incubation Time: 48 h
Result: Induced cell apoptosis in a dose-dependen manner.

Western Blot Analysis[1]

Cell Line: A375, B16F10 cells
Concentration: 0, 1, 2, 3, 4 µM
Incubation Time: 48 h
Result: Increased the expression of cleaved PARP, cleaved casepase-3, P-53 and Bax in a dose-dependent manner.
体内研究
(In Vivo)

Anti-CSCs agent-1 (5 mg/kg; i.p.; daily for 15 days) 在小鼠体内显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (A375 cells)[1]
Dosage: 5 mg/kg
Administration: I.p.; daily for 15 days
Result: Significantly inhibited tumor growth.
分子量

713.96

Formula

C44H60FN3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-CSCs agent-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-CSCs agent-12251753-58-7ApoptosismigrationROSantitumorEMTA375B16F10 cellsantiproliferativeapoptosisInhibitorinhibitorinhibit

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