2. 抗体抑制剂
  3. Biosimilar 抗体
  4. 单克隆抗体
  5. Anti-Ganglioside GD2 Antibody (14G2a)

Anti-Ganglioside GD2 Antibody (14G2a) 

目录号: HY-P990845 纯度: ≥95.0%
COA 技术支持

Anti-Ganglioside GD2 Antibody (14G2a) 是一种小鼠 IgG2a κ 嵌合抗体抑制剂，靶向人 Ganglioside GD2。Anti-Ganglioside GD2 Antibody (14G2a) 可诱导神经母细胞瘤细胞自噬和裂解。Anti-Ganglioside GD2 Antibody (14G2a) 可用于癌症的研究，如神经母细胞瘤。

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Anti-Ganglioside GD2 Antibody (14G2a)

Anti-Ganglioside GD2 Antibody (14G2a) Chemical Structure

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1 mg ￥1800
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Anti-Ganglioside GD2 Antibody (14G2a) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Ganglioside GD2 Antibody (14G2a) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human Ganglioside GD2. Anti-Ganglioside GD2 Antibody (14G2a) can induce neuroblastoma cells autophagy and lysis. Anti-Ganglioside GD2 Antibody (14G2a) can be used for the research of cancer, such as neuroblastoma[1][2].

同型

Mouse IgG2a kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

Ganglioside GD2
体外研究
(In Vitro)

Anti-Ganglioside GD2 Antibody (14G2a) (40 μg/mL, 48 h) 会增加 IMR 32 神经母细胞瘤细胞中自噬相关基因和蛋白质的表达[1]。
Anti-Ganglioside GD2 Antibody (14G2a) (1 μg/well) 会诱导 NMB-7 神经母细胞瘤靶细胞裂解[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Ganglioside GD2 Antibody (14G2a) 相关抗体:

Western Blot Analysis[1]

Cell Line: IMR-32 neuroblastoma cells
Concentration: 40 μg/mL
Incubation Time: 48 h
Result: Increased LC3A/B, ATG, caspase 3/7 PHLDA1 expression.

Cell Autophagy Assay[1]

Cell Line: IMR-32 and CHP 134 neuroblastoma cells
Concentration: 40 μg/mL
Incubation Time: 48 h
Result: Increased autophagic flux producyion.
Increased number of autophagosomes.
体内研究
(In Vivo)

Anti-Ganglioside GD2 Antibody (14G2a) (200 μg，静脉注射，在第 2、5、8、11、14、17、23、26、29、32、35、38、41 和 44 天给药) 可抑制 NMB-7 神经母细胞瘤小鼠 (BALB/c 无胸腺 (nu/nu) 小鼠) 的肿瘤生长[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NMB-7 neuroblastoma mice (BALB/c athymic (nu/nu) mice)[2]
Dosage: 200 μg
Administration: Intravenously injection, at days 2, 5, 8, 11, 14, 17, 23, 26, 29, 32, 35, 38, 41, and 44
Result: Had no detectable tumor 83 days after the initial tumor cell inoculation.
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (267 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Ganglioside GD2 Antibody (14G2a) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Ganglioside GD2 Antibody (14G2a)OthersGangliosideNeuroblastomaIMR 32CHP 134NMB-7Inhibitorinhibitorinhibit

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