2. Immunology/Inflammation
  3. PGE synthase COX
  4. Anti-inflammatory agent 78

Anti-inflammatory agent 78 (compound L-37) 是一种有效的抗炎剂。Anti-inflammatory agent 78 对 PGE2, PGE1 和 COX-2, COX-1 抑制具有显著功效。Anti-inflammatory agent 78 可以抑制 LPS 刺激的 RAW 264.7 细胞系中 NO 的释放。

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Anti-inflammatory agent 78 Chemical Structure

Anti-inflammatory agent 78 Chemical Structure

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Anti-inflammatory agent 78 相关抗体

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line[1].

IC50 & Target

COX-1

 

COX-2

 

体外研究
(In Vitro)

Anti-inflammatory agent 78 (compound L-37) 在10 μM时具有较高的肿瘤细胞生长抑制能力，对RAW 264.7细胞的生长有显着影响[1]。
Anti-inflammatory agent 78 (1-10 μM，24 h) 可抑制 RAW 264.7 细胞中 LPS 诱导的 PGE2 合成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 78 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW 264.7 cells
Concentration: 1, 5, 10 μM
Incubation Time: 24 h
Result: Inhibited LPS-induced PGE2 synthesis in a dosedependent manner. Inhibited the PGF1 production as well as the expression of COX-1, but displayed weak inhibition activity towards the Leukotrienes (LT) and Thromboxane-B2 (TXB-2) production.
体内研究
(In Vivo)

Anti-inflammatory agent 78 (compound L-37) (25-100 mg/kg, 腹腔注射) 在二甲苯诱导的小鼠耳水肿模型中表现出显着的体内抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (xylene-induced mice ear edema model)[1]
Dosage: 100 mg/kg
Administration: IP
Result: Exhibited a dose-dependent anti-inflammatory effect in vivo. L-37 has a slightly weaker inhibitory activity than celecoxib (HY-14398) in animal models, it also shows good activity and a nearly 78.14% inhibition rate at the dosage of 50 mg/kg.
分子量

355.77

Formula

C19H14ClNO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-inflammatory agent 78 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 78PGE synthaseCOXProstaglandin E synthaseCyclooxygenasePGE2Anti-inflammatoryRAW 264.7 cellInhibitorinhibitorinhibit

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Anti-inflammatory agent 78
目录号：
HY-162425
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