2. Neuronal Signaling Stem Cell/Wnt Immunology/Inflammation NF-κB Protein Tyrosine Kinase/RTK
  3. Notch Interleukin Related NF-κB VEGFR FGFR NO Synthase
  4. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 

目录号: HY-P990252
技术支持

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 是一种抗小鼠 Delta-like protein 4/DLL4 IgG 单克隆抗体。Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 可以通过阻断 DLL4-Notch 信号通路来减少血管生成和密度。Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 通过降低 NF-κB 活性和促炎因子 (IL-1β、iNOS、IL-6) 水平来减少炎症反应。Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 可以抑制 Th17 细胞分化和 IL-17A 的产生。Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 可以减少巨噬细胞浸润，缓解胰岛素抵抗。Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 可用于研究炎症、代谢疾病和癌症，如动脉粥样硬化、胰腺癌和哮喘。

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Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) Chemical Structure

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Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) is an anti-mouse Delta-like protein 4/DLL4 IgG monoclonal antibody. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce angiogenesis and density by blocking the DLL4-Notch signaling pathway. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) reduces inflammatory response by decreasing NF-κB activity and pro-inflammatory factors (IL-1β, iNOS, IL-6) levels. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can inhibit Th17 cell differentiation and IL-17A production. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can reduce macrophage infiltration and alleviate insulin resistance. Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) can be used for researches on inflammation, metabolic conditions and cancer such as atherosclerosis, pancreatic cancer and asthma[1][2][3][4].

同型

Armenian hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target[1][3][4]

NF-κB

 

iNOS

 

FGFR1

 

IL-6

 

IL-1β

 

IL-17A

 

体内研究
(In Vivo)

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) (12.5 µg/kg，腹腔注射，每 2 天或每 3 天一次，持续 15 天) 在亚致死性照射下改变 Balb/c 小鼠的骨髓血管结构，促进骨髓分化[1]。
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) (250 μg，腹腔注射，每周两次，持续 5 周) 显著抑制携带 PK-1 肿瘤的雄性 SCID 小鼠的肿瘤生长[2]。
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) (250 μg，腹腔注射，每周两次，持续 12 周) 显著改善了高脂肪和高胆固醇饮食的 Ldlr-/- 小鼠和 Lepob/Lepob 小鼠的动脉粥样硬化、胰岛素抵抗、肥胖和其他代谢异常[3]。
Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) (250 μg，腹腔注射，在第 15、18 和 21 天) 改善了 Toluene diisocyanate (TDI) 诱导的哮喘模型雌性 BALB/c 小鼠的气道炎症和哮喘症状[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice with a sub-lethally irradiation (6-8 weeks)[1]
Dosage: 12.5 µg/kg
Administration: Intraperitoneal injection (i.p.), once every 2 days or every 3 days, for 15 days
Result: Increased CD31+, VE Cadherin+ and c-kit+ vascular density.
Increased megakaryocytes (CD41+) and myeloid cells (CD11b+).
Reduced B (B220+) and T (CD3+) lymphocytes.
Upregulated the mRNA levels of IGFbp2/3, Angpt2, DLL4, DHH, and VEGF-A.
Downregulated the levels of FGF1 and CSF2.
Animal Model: 1×107 PK-1 cells injected male SCID mice (6-8 weeks)[2]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 5 weeks
Result: Significantly inhibited tumor volume.
Significantly reduced the generation and density of blood vessels.
Did not cause significant toxicity or tissue damage.
Animal Model: Ldlr-/- mice and Lepob/Lepob mice with a high fat and high cholesterol diet (8 weeks)[3]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), twice a week, for 12 weeks
Result: Reduced plaque area and MCP-1 and macrophage infiltration.
Increased collagen and reduced calcification.
Reduced fat weight and made fat cells smaller.
Reduced fasting insulin levels.
Decreased NF-κB activity and expression of pro-inflammatory cytokines (IL-1β, iNOS, IL-6).
Animal Model: TDI (0.3% ear application and 3% nebulized inhalation) induced female BALB/c mice (6-8 weeks)[4]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), on day 15, 18 and 21
Result: Significantly reduced airway hyperreactivity (AHR) and airway inflammation score.
Significantly improved epithelial damage.
Significantly reduced the total number of inflammatory cells in bronchoalveolar lavage fluid (BALF), collagen deposition and airway smooth muscle (α-SMA).
Significant decreased in the proportion of Th17 and Th1 cells.
Significant decreased in IL-17A and RORγt levels.
基因 ID

54485  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)NotchInterleukin RelatedNF-κBVEGFRFGFRNO SynthaseILNuclear factor-κBNuclear factor-kappaBVascular endothelial growth factor receptorFibroblast growth factor receptorNitric oxide synthasesNOSDelta-like protein 4/DLL4IL-1βiNOSIL-6IL-17Avascular densitymacrophageatherosclerosisasthmaPK-1Inhibitorinhibitorinhibit

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