2. Apoptosis Immunology/Inflammation Anti-infection
  3. Apoptosis Transmembrane Glycoprotein Arenavirus
  4. Anti-Mouse PSGL-1/CD162 Antibody (4RA10)

Anti-Mouse PSGL-1/CD162 Antibody (4RA10) 

目录号: HY-P990166 纯度: ≥95.0%
COA 技术支持

Anti-Mouse PSGL-1/CD162 Antibody (4RA10) 是一种源自大鼠的 IgG1 κ 型抗体抑制剂，靶向小鼠 PSGL-1/CD162。Anti-Mouse PSGL-1/CD162 Antibody (4RA10) 可阻断 PSGL 信号传导并抑制白细胞滚动。Anti-Mouse PSGL-1/CD162 Antibody (4RA10) 可用于炎症、免疫学和感染等方面的研究，如肺炎和淋巴细胞性脉络丛脑膜炎病毒感染。

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Anti-Mouse PSGL-1/CD162 Antibody (4RA10)

Anti-Mouse PSGL-1/CD162 Antibody (4RA10) Chemical Structure

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1 mg ￥2100
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Anti-Mouse PSGL-1/CD162 Antibody (4RA10) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse PSGL-1/CD162 Antibody (4RA10) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse PSGL-1/CD162. Anti-Mouse PSGL-1/CD162 Antibody (4RA10) blocks PSGL signaling and inhibits leukocyte rolling. Anti-Mouse PSGL-1/CD162 Antibody (4RA10) can be used for the researches of inflammation, immunology and infection, such as pneumonia and lymphocytic choriomeningitis virus infection[1][2][3][4].

同型

Rat IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

PSGL-1/CD162
体外研究
(In Vitro)

Anti-Mouse PSGL-1/CD162 Antibody (4RA10) (5 μg/mL) 可抑制从肺炎小鼠分离的野生型中性粒细胞形成血小板-中性粒细胞聚集体[2]。
Anti-Mouse PSGL-1/CD162 Antibody (4RA10) (5 μg/mL, 1 h) 可减少分离的野生型调节性 T 细胞的血小板-调节性 T 细胞聚集体的形成[2]。
Anti-Mouse PSGL-1/CD162 Antibody (4RA10) (10 μg/mL, 20 mins) 可抑制 CD4 T 细胞诱导的人脐静脉内皮细胞凋亡[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse PSGL-1/CD162 Antibody (4RA10) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse PSGL-1/CD162 Antibody (4RA10) (5 μg/mouse，静脉注射，单剂量) 可抑制 TNF 处理的小鼠提睾肌微循环中不依赖 P-选择素的滚动和 E-选择素介导的白细胞滚动[1]。
Anti-Mouse PSGL-1/CD162 Antibody (4RA10) (100 μg，腹腔注射，在第 4、6、8、10 和 12 天每天给药两次) 在淋巴细胞脉络丛脑膜炎病毒 (LCMV) CI13 感染的小鼠模型中显示出抗感染作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LCMV CI13-infected mice models[1]
Dosage: 100 μg
Administration: Intraperitoneally injection, twice on days 4, 6, 8, 10, and 12
Result: Increased the frequency of cytokine-producing NP(396-401)-specific and GP(33-41)-specific CD8+ T cells.
Decreased co-expression of the inhibitory receptors PD-1, LAG3, and TIM-3.
基因 ID

20345  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse PSGL-1/CD162 Antibody (4RA10) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse PSGL-1/CD162 Antibody (4RA10)ApoptosisTransmembrane GlycoproteinArenavirusPSGL-1CD162LeukocytePneumoniaT cellsLymphocytic choriomeningitis virusInhibitorinhibitorinhibit

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