2. Apoptosis Membrane Transporter/Ion Channel
  3. MDM-2/p53 P-glycoprotein
  4. Anticancer agent 50

Anticancer agent 50 (compound 6) 是一种有效的 ABCB1 外排泵调节剂。Anticancer agent 50 显示细胞毒作用和抗增殖作用。Anticancer agent 50 降低细胞周期蛋白 D1 的表达并诱导 p53 表达。Anticancer agent 50 具有研究T淋巴瘤的潜力。

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Anticancer agent 50 Chemical Structure

Anticancer agent 50 Chemical Structure

CAS No. : 2487457-15-6

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Anticancer agent 50 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma[1].

体外研究
(In Vitro)

Anticancer agent 50 (compound 6) (0-100 µM) shows cytotoxic effects with IC50s of 0.67, 0.90 µM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively[1].
Anticancer agent 50 (0-100 µM) shows antiproliferative effects with IC50s of 3.84, 1.34 µM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively[1].
Anticancer agent 50 (0.1, 0.5, 2 µM; 24 h) inhibits cell cycle progression through the reduction of the expression of cyclin D1 and inhibits cell proliferation by inducing p53 expression[1].
Anticancer agent 50 (0.1, 0.5, 2, 10 µM; 72 h) inhibits cell growth by 12% in SH-SY5Y cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 50 相关抗体:

RT-PCR[1]

Cell Line: JURKAT cells
Concentration: 0.1, 0.5, 2 µM
Incubation Time: 24 h
Result: Significantly reduced cyclin D1 expression and increased the level of p53.
分子量

563.55

Formula

C30H32N2O4Se
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 50 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 502487457-15-6Anticancer agent50Anticancer agent-50MDM-2/p53P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243JURKAT cellscyclin D1p53T-lymphomaSH-SY5Y cellsInhibitorinhibitorinhibit

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