2. Cell Cycle/DNA Damage
  3. Antifolate
  4. Antifolate agent 1

Antifolate agent 1 (Compound 1) 是一种具有单碳桥的抗叶酸 (antifolate) 剂。Antifolate agent 1 缺乏 RFC 转运，对 FRα 和 FRβ 无亲和力，且无 GARFTase 抑制活性。Antifolate agent 1 可作为阴性对照用于叶酸受体靶向抗叶酸剂开发。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Antifolate agent 1

Antifolate agent 1 Chemical Structure

CAS No. : 518063-75-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Antifolate agent 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antifolate agent 1 (Compound 1) is an antifolate agent with one-carbon bridge. Antifolate agent 1 lacks RFC transport and has no affinity for FRα and FRβ and no GARFTase inhibitory activity. Antifolate agent 1 can be used as a negative control for the development of folate receptor-targeting antifolates[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
IGROV-1 IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells
Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells
[PMID: 18680275]
IGROV-1 IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells in presence of folic acid
Antiproliferative activity against human RFC and FRalpha expressing human IGROV1 cells in presence of folic acid
[PMID: 18680275]
KB IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC and FRalpha expressing human KB cells
Antiproliferative activity against human RFC and FRalpha expressing human KB cells
[PMID: 18680275]
KB IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC and FRalpha expressing human KB cells in presence of folic acid
Antiproliferative activity against human RFC and FRalpha expressing human KB cells in presence of folic acid
[PMID: 18680275]
KB IC50
> 1000 nM
Compound: 1
Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserine
Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserine
[PMID: 18680275]
R2 IC50
> 1000 nM
Compound: 1
Antiproliferative activity against human RFC expressing Chinese hamster R2 cells
Antiproliferative activity against human RFC expressing Chinese hamster R2 cells
[PMID: 18680275]
分子量

413.38

Formula

C19H19N5O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antifolate agent 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifolate agent 1518063-75-7Antifolate agent1Antifolate agent-1AntifolateOne-carbon bridgeRFCFRαFRβGARFTaseNegative controlInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Antifolate agent 1
目录号：
HY-175428
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z