2. 疾病领域
  3. 癌症
  4. Antitumor agent-129

Antitumor agent-129 (Compound 68) 是一种噻唑烷-4-磺酮衍生物和骨肉瘤 (OS) 抑制剂，抑制 OS 细胞活性的 IC50 值为 0.217 μM，半衰期为 73.8 min (小鼠肝微粒体)，具有良好的药代动力学特征 (体内生物利用度 F = 115%，腹腔给药)。Antitumor agent-129 是 OS 研究的潜在候选物。

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Antitumor agent-129

Antitumor agent-129 Chemical Structure

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Antitumor agent-129 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-129 (Compound 68) is a thiazolidin-4-one sulfone derivative and an Osteosarcoma (OS) inhibitor with an IC50 value of 0.217 μM, a half-life of 73.8 min (mouse liver microsome) and an excellent pharmacokinetic profile (in vivo bioavailability F = 115%, intraperitoneal administration). Antitumor agent-129 is a potential candidate for OS research[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
143B IC50
0.295 μM
Compound: 68
Antiproliferative activity against human 143B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human 143B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
A549 IC50
1.891 μM
Compound: 68
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
HOS-TE85 IC50
0.217 μM
Compound: 68
Antiproliferative activity against human MNNG/HOS cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MNNG/HOS cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
HOS-TE85 IC50
0.277 μM
Compound: 68
Antiproliferative activity against human MNNG/HOS cells transfected with DDX5 shRNA assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MNNG/HOS cells transfected with DDX5 shRNA assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
MG-63 IC50
1.092 μM
Compound: 68
Antiproliferative activity against human MG-63 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MG-63 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
MGC-803 IC50
0.394 μM
Compound: 68
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
PC-3 IC50
4.3 μM
Compound: 68
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
SAOS-2 IC50
0.43 μM
Compound: 68
Antiproliferative activity against human SAOS-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SAOS-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
SJSA-1 IC50
0.304 μM
Compound: 68
Antiproliferative activity against human SJSA-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human SJSA-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay
[PMID: 38232462]
分子量

448.49

Formula

C20H24N4O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-129 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-129Antitumor agent129Antitumor agent 129OthersOsteosarcoma Inhibitorthiazolidin-4-one sulfone derivativeInhibitorinhibitorinhibit

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