2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. Apelin-13

Apelin-13 是 G 蛋白偶联受体angiotensin II protein J (APJ) 的内源性配体，激活G蛋白偶联受体的 EC 50 值为 0.37 nM。Apelin-13 广泛分布于中枢和外周神经系统。Apelin-13 具有扩张血管和降压作用。Apelin-13 也可用于 2 型糖尿病综合征的研究。

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Custom Peptide Synthesis

Apelin-13

Apelin-13 Chemical Structure

CAS No. : 217082-58-1

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规格 价格 是否有货 数量
1 mg ￥550
In-stock
5 mg ￥1650
In-stock
10 mg ￥2800
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Apelin-13:

Apelin-13 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome[1][2][3].

IC50 & Target

IC50: 0.37 nM (APJ)[1]
体内研究
(In Vivo)

Apelin-13 (200 µg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels[2].
Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)[2]
Dosage: 200 µg/kg
Administration: IP, daily for 4 weeks
Result: Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.
Animal Model: Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)[4]
Dosage: 10 and100 μM
Administration: ICV, single dosage
Result: Increased the spontaneous discharges in the majority of pallidal neurons.
Clinical Trial
分子量

1550.83

Formula

C69H111N23O16S
CAS 号
性状

固体

颜色

White to off-white

Sequence

Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Shortening

QRPRLSHKGPMPF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (64.48 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6448 mL 3.2241 mL 6.4482 mL
5 mM 0.1290 mL 0.6448 mL 1.2896 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Apelin-13 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6448 mL 3.2241 mL 6.4482 mL 16.1204 mL
5 mM 0.1290 mL 0.6448 mL 1.2896 mL 3.2241 mL
10 mM 0.0645 mL 0.3224 mL 0.6448 mL 1.6120 mL
15 mM 0.0430 mL 0.2149 mL 0.4299 mL 1.0747 mL
20 mM 0.0322 mL 0.1612 mL 0.3224 mL 0.8060 mL
25 mM 0.0258 mL 0.1290 mL 0.2579 mL 0.6448 mL
30 mM 0.0215 mL 0.1075 mL 0.2149 mL 0.5373 mL
40 mM 0.0161 mL 0.0806 mL 0.1612 mL 0.4030 mL
50 mM 0.0129 mL 0.0645 mL 0.1290 mL 0.3224 mL
60 mM 0.0107 mL 0.0537 mL 0.1075 mL 0.2687 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apelin-13217082-58-1Apelin13Apelin 13Apelin Receptor (APJ)nervous systemsvasodilatoryantihypertensivediabetesmetabolic syndromeinsulin resistancelipidpallidal neuronsGoto-Kakizaki ratWistar ratInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
Apelin-13
目录号：
HY-P1944
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