2. Apoptosis
  3. Apoptosis Caspase
  4. Apoptosis inducer 52

Apoptosis inducer 52 是一种是氟他胺的衍生物，在前列腺癌细胞中诱导凋亡 (apoptosis)。Apoptosis inducer 52 通过激活内源性和外源性凋亡途径促进细胞凋亡，且不产生活性氧 (ROS)。Apoptosis inducer 52 触发 caspase 3/7 活性，并使磷脂酰丝氨酸外翻，导致细胞周期在 G0/G1期停滞。Apoptosis inducer 52 可用于雄激素受体 (AR) 依赖性和非依赖性前列腺癌和白血病的研究。

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Apoptosis inducer 52

Apoptosis inducer 52 Chemical Structure

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Apoptosis inducer 52 相关抗体

Top Publications Citing Use of Products

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 52 is a derivative of flutamide that induces apoptosis in prostate cancer cells. Apoptosis inducer 52 promotes apoptosis by activating both intrinsic and extrinsic apoptotic pathways, without generating reactive oxygen species (ROS). Apoptosis inducer 52 triggers caspase 3/7 activity and the externalization of phosphatidylserine, leading to cell cycle arrest at the G0/G1 phase. Apoptosis inducer 52 can be used for the research of androgen receptor (AR)-dependent and -independent prostate cancers and leukemia[1].

IC50 & Target[1]

Caspase 3

 

Caspase-7

 

Caspase-8

 

Caspase-9

 

体外研究
(In Vitro)

Apoptosis inducer 52 (compoun a5) (1-100 μM；48 h；LNCaP) 对 LNCaP 和非恶性 HaCaT 细胞的抑制作用 IC50 值分别为 8.89 µM 和 28.71 µM[1]。
Apoptosis inducer 52 对白血病亚组 K-562 细胞系表现出显著的抗增殖活性[1]。
Apoptosis inducer 52 (10 μM；24-48 小时；LNCaP) 随时间依赖性诱导细胞凋亡[1]。
Apoptosis inducer 52 (10 μM；48 h；LNCaP) 使细胞周期停滞在 G0/G1 期[1]。
Apoptosis inducer 52 (10 μM；48 h；LNCaP) 增加 caspase 3、8、9 的表达并上调 BAX[1]。
Apoptosis inducer 52 (10 μM; 12-24 h; LNCaP) 轻微增加 ROS 产生。结果表明，Apoptosis inducer 52 诱导的细胞凋亡可能不依赖于活性氧 (ROS)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 52 相关抗体:

Cell Viability Assay[1]

Cell Line: LNCaP and HaCaT cells
Concentration: 1, 2.5, 5, 10, 25, 50, 100 μM
Incubation Time: 48 h
Result: Cell viability decreased in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: LNCaP
Concentration: 10 μM
Incubation Time: 24, 48 h
Result: The ratio of apoptotic cells increased significantly at the end of the 48 h.
Caspase 3/7 activity increased and phosphatidylserine externalization was observed.

Cell Cycle Analysis[1]

Cell Line: LNCaP
Concentration: 10 μM
Incubation Time: 48 h
Result: Inhibited the cell cycle progression by arresting the cells in the G0/G1 phase.

Western Blot Analysis[1]

Cell Line: LNCaP
Concentration: 10 μM
Incubation Time: 48 h
Result: Expression levels of pro-caspase 3, pro-caspase 9, caspase 3, caspase 9, caspase 8 increased, and BAX levels were upregulated.
分子量

546.32

Formula

C22H15F6N3O2Se
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 52 相关分类

  • 摩尔计算器

  • 稀释计算器

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 52Apoptosis inducer52Apoptosis inducer-52ApoptosisCaspaseapoptosis,derivative of flutamide,caspase 3/7,prostate cancerInhibitorinhibitorinhibit

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