1. PROTAC
    Others
  2. PROTACs
    Androgen Receptor
  3. ARD-2585

ARD-2585 

目录号: HY-139436
产品使用指南

ARD-2585 是有效的、具有口服活性的雄激素受体 (androgen receptor) 的PROTAC 降解剂。

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ARD-2585 Chemical Structure

ARD-2585 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
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  • 生物活性

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  • 参考文献

生物活性

ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor[1].

体外研究
(In Vitro)

ARD-2585 achieves DC50 values of 0.04-0.1 nM in the VCaP cell line with AR gene amplification and in the LNCaP cell line carrying an AR mutation[1].
ARD-2585 (100 nM) is effective in reducing the AR protein level at the 3 and 24 h time-points by 78% (p < 0.01) and 60% at the 6 h time-point (p > 0.05)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

763.28

Formula

C₄₁H₄₃ClN₈O₅

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
ARD-2585
目录号:
HY-139436
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