2. Metabolic Enzyme/Protease Others
  3. Cytochrome P450 Endogenous Metabolite Drug Isomer
  4. Aspergillusidone F

Aspergillusidone F (Compound 3) 是一种溴化缩酚酸酮，是 Aspergillusidone D (HY-N16402) 的区域异构体。Aspergillusidone F 是一种芳香化酶 (Aromatase) 抑制剂，其 IC50 为 0.5 μM。Aspergillusidone F 可从 KBr 培养基培养的真菌 Aspergillus unguis 中分离得到。Aspergillusidone F 对癌细胞 (如 MOLT-3 细胞) 具有强效细胞毒性。Aspergillusidone F 可用于乳腺癌等癌症的研究。

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Aspergillusidone F

Aspergillusidone F Chemical Structure

CAS No. : 1558007-47-8

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Aspergillusidone F 相关抗体

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查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

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生物活性

Aspergillusidone F (Compound 3), a brominated depsidone, is a regioisomer of Aspergillusidone D (HY-N16402). Aspergillusidone F is a Aromatase inhibitor with an IC50 of 0.5  μM. Aspergillusidone F can be isolated from fungus Aspergillus unguis cultured in KBr medium. Aspergillusidone F has potent cytotoxicity against cancers cells, such as MOLT-3 cells. Aspergillusidone F can be used for cancers like breast cancer research[1].

IC50 & Target[1].

Aromatase

0.5 μM (IC50)

Fungal Metabolite

 

分子量

484.14

Formula

C19H16Br2O5
CAS 号
结构分类
初始来源

Aspergillus unguis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aspergillusidone F 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Aspergillusidone F1558007-47-8Cytochrome P450Endogenous MetaboliteDrug IsomerCYPsBrominated depsidoneRegioisomerAromataseAspergillus unguisHuCCA-1 cellsHepG2 cellsA549 cellsMOLT-3 cellsBreast cancerInhibitorinhibitorinhibit

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