2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Phosphodiesterase (PDE) LPL Receptor
  4. ATX inhibitor 27

ATX inhibitor 27 (Compound 31) 是一种 ATX 抑制剂。ATX inhibitor 27 对人体自分泌运动因子 (hATX) 和溶血磷脂酰胆碱 (LPC) 的 IC50 分别为 13 nM 和 23 nM。ATX inhibitor 27 通过抑制 ATX 酶，降低体内 LPA 水平。ATX inhibitor 27 能够用于炎症、神经退行性疾病和癌症等与 ATX-LPA 相关疾病的研究。

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ATX inhibitor 27

ATX inhibitor 27 Chemical Structure

CAS No. : 2023027-81-6

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ATX inhibitor 27 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

查看 LPL Receptor 亚型特异性产品:

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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  • 纯度 & 产品资料

  • 参考文献

生物活性

ATX inhibitor 27 (Compound 31) is an ATX inhibitor. The IC50 values of ATX inhibitor 27 against human autotaxin (hATX) and lysophosphatidylcholine (LPC) are 13 nM and 23 nM, respectively. ATX inhibitor 27 reduces LPA levels in vivo by inhibiting ATX enzyme. ATX inhibitor 27 can be used in the study of ATX-LPA-related diseases such as inflammation, neurodegenerative diseases and cancer[1].

分子量

491.97

Formula

C26H26ClN5O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATX inhibitor 27 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

ATX inhibitor 272023027-81-6ATX inhibitor27ATX inhibitor-27Phosphodiesterase (PDE)LPL ReceptorLysophospholipid ReceptorATXLPALPCDELWistar ratGPCRInhibitorinhibitorinhibit

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