2. Apoptosis
  3. Necroptosis RIP kinase
  4. AZ'320

AZ'320 是一种 ATP 竞争性坏死性凋亡 (necroptosis) 抑制剂 (EC50 值为 4.9 μM)，以及 RIPK1 抑制剂 (pKD 值为 5.45)。AZ'320 通过抑制 RIPK1 磷酸化来抑制坏死性凋亡 (necroptosis)。AZ'320 可降低全身性炎症反应综合征 (SIRS) 模型小鼠的死亡率，并恢复体温和体重。AZ'320 可以被用于癌症和炎症的研究。

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AZ'320

AZ'320 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

AZ'320 相关抗体

Top Publications Citing Use of Products

查看 RIP kinase 亚型特异性产品:

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RIPK1 RIPK2 RIPK3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZ'320 is an ATP-competitive necroptosis (EC50 of 4.9 μM) inhibitor and a RIPK1 (pKD of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researches of cancer and inflammation[1].

体外研究
(In Vitro)

AZ’320 (0.1-10 μM, 4 h) 呈剂量依赖性地抑制 12.1 细胞中 RIPK1 Ser166 位点的磷酸化水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AZ'320 相关抗体:

Western Blot Analysis[1]

Cell Line: I2.1 FADD−/− human Jurkat cells
Concentration: 01, 1, 5 and 10 μM
Incubation Time: 4 h
Result: Dose-dependently inhibited the levels of RIPK1 Ser166 phosphorylation.
体内研究
(In Vivo)

AZ'320 (5 mg/kg，静脉注射，TNF 刺激前 15 分钟给药) 可降低全身性炎症反应综合征 (SIRS) 模型小鼠的死亡率，并恢复体温和体重，达到与 Nec-1 (HY-15760) 相近的程度[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Systemic inflammatory response syndrome (SIRS) mice models (C57BL/6, male, 6-8 weeks)[1]
Dosage: 5 mg/kg
Administration: Intravenously injection, 15 min before 96 h of 0.5 mg/kg TNF stimulation
Result: Prevented mortality of the mice and rescued temperature and body weight to a similar degree as Nec-1 (HY-15760).
分子量

416.51

Formula

C20H20N2O4S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AZ'320 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ'320NecroptosisRIP kinaseReceptor-interacting protein kinasesRIPKReceptor-interacting kinase 1 (RIPK1)I2.1 FADD?/? human Jurkat cellsSystemic inflammatory response syndrome (SIRS)Inhibitorinhibitorinhibit

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产品名称：
AZ'320
目录号：
HY-174820
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