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    Immunology/Inflammation
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  3. AZD2423

AZD2423 

目录号: HY-135891
产品使用指南

AZD2423 是一种有效的、选择性的、口服生物利用的、非竞争性的 CCR2 趋化因子受体负向变构调节剂。AZD2423 对 CCR2 Ca2+ 通量的 IC50 为 1.2 nM。

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AZD2423 Chemical Structure

AZD2423 Chemical Structure

CAS No. : 1229603-37-5

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Description

AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. AZD2423 has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].

IC50 & Target[1]

CCR2

 

In Vitro

AZD2423 inhibits MCP-1 induced calcium mobilization and chemotaxis of THP-1 cell line with an IC50 of 4 nM[1].

Molecular Weight

425.93

Formula

C₂₀H₂₉ClFN₅O₂

CAS No.

1229603-37-5

SMILES

O=C(N1CCN(C([C@@H]2NCCN(C(C)(C)C)C2)=O)CC1)NC3=CC=C(Cl)C(F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AZD2423AZD 2423AZD-2423CCRCC chemokine receptorchemokineoralmonocytechemotaxispainneuropathicInhibitorinhibitorinhibit

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产品名称:
AZD2423
目录号:
HY-135891
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