2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. Betavulgarin

Betavulgarin 是一种 抗癌剂。Betavulgarin 可以从甜菜 (Beta vulgaris) 中分离出来。Betavulgarin 抑制乳腺癌细胞的增殖、迁移、集落形成和乳腺肿瘤球形成，并减少 CD44+/CD24− 亚群的规模以及自我更新相关基因 C-Myc、Nanog 和 Oct4 的表达。Betavulgarin 通过调控 Stat3/Sox2 信号转导促进 BCSCs 死亡。

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Betavulgarin

Betavulgarin Chemical Structure

CAS No. : 51068-94-1

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Betavulgarin 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Betavulgarin is an anticancer agent. Betavulgarin can be isolated from Sugar Beet (Beta vulgaris). Betavulgarin suppresses the proliferation, migration, colony formation, and mammosphere formation of breast cancer cells, and reduces the size of the CD44+/CD24− subpopulation and the expression of the self-renewal- related genes C-Myc, Nanog and Oct4. Betavulgarin promotes BCSCs death through the regulation of Stat3/Sox2 signaling[1].

IC50 & Target[1]

p-STAT3

 

体外研究
(In Vitro)

Betavulgarin (50-500 μM, 24 小时) 显著抑制 MDA-MB-231 细胞和 MCF-7 细胞的增殖、迁移、集落形成和乳腺肿瘤球形成[1]。
Betavulgarin (200 μM, 24 小时) 可减少 MDA-MB-231 细胞中 CD44+/CD24− 亚群的大小，细胞比例从 90.4% 降至 57.2%[1]。
Betavulgarin (200 μM, 48 小时) 可抑制 MDA-MB-231 细胞来源的乳腺肿瘤球中 Stat3 的易位，降低 p-Stat3 的总蛋白水平和核蛋白水平以及 SOX2 的 mRNA 和蛋白水平[1]。
Betavulgarin (200 μM, 48 小时) 显著抑制 MDA-MB-231 细胞来源的乳腺肿瘤球中 Stat3 结合 DNA 的能力[1]。
Betavulgarin (24-72 小时) 降低 BCSCs 来源的乳腺肿瘤球中自我更新相关基因 C-Myc、Nanog 和 Oct4 的 mRNA 表达，并抑制其生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Betavulgarin 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 cells, MCF-7 cells
Concentration: 50, 100, 200, 300, 400, 500 μM
Incubation Time: 24 h
Result: Suppressed the proliferation of MDA-MB-231 and MCF-7 cells at ≥ 100 µM and 50 µM, respectively.

Cell Migration Assay [1]

Cell Line: MDA-MB-231 cells, MCF-7 cells
Concentration: 100 μM
Incubation Time: 24 h
Result: Inhibited migration of MDA-MB-231 and MCF-7 cells.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells, MCF-7 cells
Concentration: 200 μM
Incubation Time: 48 h
Result: Inhibited the translocation of Stat3, and significantly decreased the total protein levels and nuclear protein level of Stat3 and p-Stat3, as well as the protein levels of SOX2 in MDA-MB-231-derived mammospheres.

Immunofluorescence[1]

Cell Line: MDA-MB-231 cells, MCF-7 cells
Concentration: 200 μM
Incubation Time: 48 h
Result: Reduced the level of nuclear pStat3 in MDA-MB-231 cells.

Real Time qPCR[1]

Cell Line: MDA-MB-231 cells
Concentration: 200 μM
Incubation Time: 48 h
Result: Reduced the mRNA level of SOX2 in MDA-MB-231-derived mammospheres.
分子量

312.27

Formula

C17H12O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Betavulgarin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betavulgarin51068-94-1STATInhibitorsAnticancerBCSCsMammospheresStat3SOX2MDA-MB-231MCF-7 cellsInhibitorinhibitorinhibit

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