2. Anti-infection
  3. Parasite
  4. Betulonaldehyde

Betulonaldehyde 是一种五环三萜类化合物，可从 Diospyros filipendula 中分离出来。Betulonaldehyde 具有抗疟原虫活性 (IC50: 3.36 µg/mL)。Betulonaldehyde 对 NCI H187 肺癌细胞和非癌性 Vero 细胞具有细胞毒性 (IC50 分别为 19.23 和 17.09 µg/mL)。Betulonaldehyde 可抑制 Phorbol 12-myristate 13-acetate (HY-18739) 在小鼠中诱发的炎症。

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Betulonaldehyde

Betulonaldehyde Chemical Structure

CAS No. : 4439-98-9

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规格 价格 是否有货 数量
5 mg ￥2524
3 - 4 周
10 mg ￥4039
3 - 4 周
25 mg 询价 3 - 4 周
50 mg 询价 3 - 4 周
100 mg 询价 3 - 4 周
200 mg   询价  
500 mg   询价  

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Betulonaldehyde 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

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  • 参考文献

生物活性

Betulonaldehyde is a pentacyclic triterpenoid that can be isolated from Diospyros filipendula. Betulonaldehyde has antiplasmodial activity (IC50: 3.36 µg/mL). Betulonaldehyde has cytotoxic to NCI H187 lung cancer cells and non-cancerous Vero cells (IC50s: 19.23 and 17.09 µg/mL, respectively). Betulonaldehyde inhibits Phorbol 12-myristate 13-acetate (HY-18739) induced inflammation in mice[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
B16 ED50
0.35 μM
Compound: 10
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
[PMID: 12027734]
B16 IC50
4.1 μM
Compound: 10
Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
[PMID: 12027734]
H9 EC50
45.6 μM
Compound: 30
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound able to suppress HIV replication by 50%.
[PMID: 9804704]
H9 IC50
49 μM
Compound: 30
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound toxic to 50% of mock-infected H9 cells.
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound toxic to 50% of mock-infected H9 cells.
[PMID: 9804704]
KB ED50
12.9 μg/mL
Compound: 7
Cytotoxicity against human epidermoid carcinoma of the mouth (KB) cell line.
Cytotoxicity against human epidermoid carcinoma of the mouth (KB) cell line.
[PMID: 9873420]
MT2 CC50
20 μM
Compound: 38
Cytotoxicity against mock-infected human MT2 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer Glo assay
Cytotoxicity against mock-infected human MT2 cells assessed as reduction in cell viability incubated for 48 hrs by cell-titer Glo assay
[PMID: 25927586]
MT2 IC50
4.2 μM
Compound: 38
Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth measured 48 hrs post infection by luminometry
Antiviral activity against HIV1 NL4.3-Ren infected in human MT2 cells assessed as inhibition of viral growth measured 48 hrs post infection by luminometry
[PMID: 25927586]
SK-MEL-2 ED50
7.4 μg/mL
Compound: 7
Cytotoxicity against cultured human melanoma (MEL-2) cell line.
Cytotoxicity against cultured human melanoma (MEL-2) cell line.
[PMID: 9873420]
分子量

438.69

Formula

C30H46O2
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Betulonaldehyde 相关分类

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betulonaldehyde4439-98-9ParasiteInhibitorinhibitorinhibit

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