1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Bifemelane hydrochloride

Bifemelane hydrochloride (Synonyms: MCI-2016)

目录号: HY-B1558A
产品使用指南

Bifemelane hydrochloride 是一种有效,选择性和竞争性的单胺氧化酶 A (MAO-A) 抑制剂,Ki 值为 4.20 μM,它也非竞争性地抑制 MAO-BKi 为 46.0 μM。Bifemelane hydrochloride 具有很强的抗抑郁活性,可用于研究与脑血管疾病有关的认知和情绪障碍。

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Bifemelane hydrochloride Chemical Structure

Bifemelane hydrochloride Chemical Structure

CAS No. : 62232-46-6

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Description

Bifemelane hydrochloride is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A), with a Ki of 4.20 μM, and it also inhibits MAO-B noncompetitively with a Ki of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease[1][2].

IC50 & Target[1]

MAO-A

4.2 μM (Ki)

MAO-B

46 μM (Ki)

In Vitro

Bifemelane inhibits MAO-A in a dose-dependent manner, with Kis of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively[1].
Bifemelane inhibits MAO-B activities in a dose-dependent manner, with Kis of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively[1].

In Vivo

Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test[3].
Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg[3].

Animal Model: Wistar male rats (230-270 g) are induced hypothermia by Reserpine[3]
Dosage: 20, 40, 80 mg/kg
Administration: A single i.p.
Result: Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃.
Molecular Weight

305.84

Formula

C₁₈H₂₄ClNO

CAS No.

62232-46-6

中文名称

盐酸双芬麦兰

SMILES

CNCCCCOC1=CC=CC=C1CC2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

BifemelaneMCI-2016MCI2016MCI 2016Monoamine OxidaseMAOmonoamineoxidaseAMAO-AMAO-BantidepressantInhibitorinhibitorinhibit

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Bifemelane hydrochloride
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HY-B1558A
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